Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths
Impaired stress-induced pressure natriuresis increases cardiovascular load in African American youths
复制标题
DOI：
10.1016/s0895-7061(02)02994-1
复制
发表时间：
2002-10-01
影响因子：
3.2
通讯作者：
Treiber, FA
中科院分区：
文献类型：
--
作者：
Harshfield, GA;Wilson, ME;Treiber, FA
背景资料：我们假设，受损的压力引起的压力尿钠排泄增加血压（BP）load.Methods：118名非洲裔美国青年被带入类似水平的钠平衡。该协议包括2小时的基线期，1小时的应激期（竞争性视频游戏），和2小时的恢复period.Results：正常压力尿钠排泄（n = 80）导致阻力介导的（r = 0.23; P <0.03）血压升高（P <0.001）。相反，压力性尿钠排泄受损（n = 38）导致血压升高时间延长（P <0.05），这是由血压（P <0.001）的容积介导（r = 0.55; P <0.002）增加所致。结论：压力性尿钠排泄受损可能有助于原发性高血压的发展，特别是在非洲裔美国人中。(C)2002年美国高血压杂志有限公司
Background: We hypothesized that impaired stress-induced pressure natriuresis increases blood pressure (BP) load.Methods: The 118 African American youths were brought into similar levels of sodium balance. The protocol consisted of a 2-h baseline period, a 1-h stress period (competitive video games), and a 2-h recovery period.Results: Normal pressure natriuresis (n = 80) resulted from a resistance-mediated (r = 0.23; P < .03) increase in BP (P < .001). In contrast, impaired pressure natriuresis (n = 38), leading to an extended period of elevated BP (P < .05), resulted from a volume-mediated (r = 0.55; P < .002) increase in BP (P < .001).Conclusions: Impaired stress-induced pressure natriuresis may contribute to the development of essential hypertension, particularly in African Americans. (C) 2002 American Journal of Hypertension, Ltd.