Cardiovascular responses to hemorrhage and naloxone in conscious barodenervated rabbits.
Cardiovascular responses to hemorrhage and naloxone in conscious barodenervated rabbits.
复制标题
清醒的压力去神经兔的心血管对出血和纳洛酮的反应。
DOI：
10.1152/ajpregu.1986.251.5.r909
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Gaddis,RR
中科院分区：
文献类型：
--
作者：
Schadt,JC;Gaddis,RR
在完全去窦弓神经（SAD）之前和之后，评估血流动力学和血浆儿茶酚胺对肿胀出血和随后用纳洛酮阻断阿片受体的反应。本研究旨在验证阿片类药物介导的压力感受性反射失败导致出血性低血压的一般假设。我们检验的特定假设是SAD会消除纳洛酮阿片受体阻滞剂的升压作用。这些研究是在清醒的长期准备的兔子中进行的。由于心率和血管阻力的代偿性增加，12 ml/kg的出血未改变完整动物的平均动脉血压。当失血量超过12 ml/kg时，由于血管阻力降低，压力突然降低。血浆去甲肾上腺素（NE）和肾上腺素（E）在出血后较出血前升高。血浆E水平增加了近70倍。SAD后，平均血压在出血开始时开始下降，心率增加消失，血管阻力在整个失血过程中下降。出血后血浆NE与出血前无明显差异。血浆E增加，但增加仅为5倍。纳洛酮增加SAD前后的平均动脉血压、血管阻力、心脏指数和血浆NE。SAD后血压和血浆去甲肾上腺素的增加显著更大。因此，纳洛酮在该模型中的升压作用不是由于压力反射敏感性增加。相反，完整的压力反射缓冲纳洛酮的作用。
The hemodynamic and plasma catecholamine response to hypotensive hemorrhage and subsequent opioid receptor blockade with naloxone were evaluated before and after complete sinoaortic denervation (SAD). This study was done to test the general hypothesis that opioid-mediated failure of the baroreflex accounts for the hypotension of hemorrhage. The specific hypothesis we tested was that SAD would abolish the pressor effect of opioid receptor blockade with naloxone. The studies were done in conscious chronically prepared rabbits. Hemorrhage of 12 ml/kg did not change mean arterial blood pressure in intact animals due to a compensatory increase in heart rate and vascular resistance. When blood loss exceeded 12 ml/kg, pressure decreased abruptly due to a decrease in vascular resistance. Plasma norepinephrine (NE) and epinephrine (E) were higher after hemorrhage than before. Plasma E levels increased almost 70 times. After SAD, mean blood pressure began to decrease at the beginning of hemorrhage, the heart rate increase was abolished, and vascular resistance decreased throughout the blood loss. Plasma NE was no different after hemorrhage than before. Plasma E increased, but the increase was only fivefold. Naloxone increased mean arterial blood pressure, vascular resistance, cardiac index, and plasma NE before and after SAD. The increases in blood pressure and plasma norepinephrine were significantly greater after SAD. Therefore the pressor effect of naloxone in this model is not due to increased baroreflex sensitivity. Rather, intact baroreflexes buffer naloxone's effects.