Removal of non-steroidal anti-inflammatory drugs ibuprofen and ketoprofen from water by emulsion liquid membrane
Removal of non-steroidal anti-inflammatory drugs ibuprofen and ketoprofen from water by emulsion liquid membrane
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DOI：
10.1007/s11356-013-2140-9
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发表时间：
2014-02-01
影响因子：
5.8
通讯作者：
Hamdaoui, Oualid
中科院分区：
文献类型：
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作者：
Daas, Attef;Hamdaoui, Oualid
本工作采用乳化液膜（ELM）去除世界范围内的非甾体类抗炎药布洛芬（IBP）和酮洛芬（KTP）。 ELM体系由己烷作为稀释剂、Span 80作为表面活性剂和碳酸钠作为内部水溶液组成。考察了表面活性剂浓度、乳化时间、外相硫酸浓度、外相酸类型、内相浓度、内相类型、搅拌速度、内相与膜相体积比、处理比、IBP初始浓度、稀释剂类型和盐等实验条件对IBP提取的影响。所得结果表明，通过适当选择操作参数，即使在高浓度盐存在的情况下，也可以从进料溶液中提取几乎所有的 IBP 分子。在最佳操作条件下，从蒸馏水（99.3％）、天然矿泉水（97.3％）和海水（94.0％）中去除IBP的效率相当，这表明ELM处理工艺代表了一种非常有趣的从复杂基质（例如天然水和海水）中去除IBP的先进分离工艺。在优化的实验条件下，大约 97.4% 的 KTP 在不到 20 分钟的接触时间内被去除。
In this work, the removal of the worldwide non-steroidal anti-inflammatory drugs ibuprofen (IBP) and ketoprofen (KTP) by emulsion liquid membrane (ELM) was carried out. An ELM system is made up of hexane as diluent, Span 80 as the surfactant and sodium carbonate as the inner aqueous solution. Effect of experimental conditions that affect the extraction of IBP such as surfactant concentration, emulsification time, sulfuric acid concentration in external phase, acid type in external phase, internal phase concentration, type of internal phase, stirring speed, volume ratio of internal phase to membrane phase, treatment ratio, IBP initial concentration, diluent type and salt was investigated. The obtained results showed that by appropriate selection of the operational parameters, it was possible to extract nearly all of IBP molecules from the feed solution even in the presence of high concentration of salt. Under optimum operating conditions, the efficiencies of IBP removal from distilled water (99.3 %), natural mineral water (97.3 %) and sea water (94.0 %) were comparable, which shows that the ELM treatment process represents a very interesting advanced separation process for the removal of IBP from complex matrices such as natural and sea waters. Under the optimized experimental conditions, approximately 97.4 % KTP was removed in less than 20 min of contact time.