THE NEOSTRIATAL MOSAIC - STRIATAL PATCH-MATRIX ORGANIZATION IS RELATED TO CORTICAL LAMINATION
THE NEOSTRIATAL MOSAIC - STRIATAL PATCH-MATRIX ORGANIZATION IS RELATED TO CORTICAL LAMINATION
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DOI：
10.1126/science.2799392
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发表时间：
1989-10-20
期刊：
影响因子：
56.9
通讯作者：
GERFEN, CR
中科院分区：
文献类型：
--
作者：
GERFEN, CR
纹状体是基底神经节的主要组成部分，它处理来自几乎所有大脑皮层区域的输入，以影响运动、情感和认知行为。这些看似完全不同的功能是如何整合的，这些研究表明，哺乳动物的纹状体是由两个隔室组成的，它们排列成马赛克，即斑块和基质，它们的神经化学和神经解剖学特性不同。在这项研究中，从前额叶，扣带和运动皮质区的纹状体室的预测进行了检查与菜豆-白细胞凝集素（PHA-L）顺行轴突示踪剂在大鼠。每个皮质区项目的补丁和矩阵的纹状体，但是，深层V和VI层皮质纹状体神经元项目主要的补丁，而浅层V和VI层皮质纹状体神经元项目主要的补丁，而浅层V和III和II层皮质纹状体神经元项目主要的矩阵。补丁和矩阵corticostriatal预测的相对贡献各不相同的皮质区检查，使allocortical地区提供了更多的输入到补丁比矩阵，而相反获得新皮质区。这些结果表明，皮质纹状体输入的隔室组织与其层流起源，其次是起源的cytoarchitectonic地区。
The basal ganglia, of which the striatum is the major component, process inputs from virtually all cerebral cortical areas to affect motor, emotional, and cognitive behaviors. Insights into how these seemingly disparate functions may be integrated have emerged from studies that have demonstrated that the mammalian striatum is composed of two compartments arranged as a mosaic, the patches and the matrix, which differ in their neurochemical and neuroanatomical properties. In this study, projections from prefrontal, cingulate, and motor cortical areas to the striatal compartments were examined with the Phaseolus vulgaris-leucoagglutinin (PHA-L) anterograde axonal tracer in rats. Each cortical area projects to both the patches and the matrix of the striatum; however, deep layer V and layer VI corticostriatal neurons project principally to the patches, whereas superficial layer V and layer VI corticostriatal neurons project principally to the patches whereas superficial layer V and layer III and II corticostriatal neurons project principally to the matrix. The relative contribution of patch and matrix corticostriatal projections varies among the cortical areas examined such that allocortical areas provide a greater number of inputs to the patches than to the matrix, whereas the reverse obtains for neocortical areas. These results demonstrate that the compartmental organization of corticostriatal inputs is related to their laminar origin and secondarily to the cytoarchitectonic area of origin.