ALPHA-INHIBIN IS A TUMOR-SUPPRESSOR GENE WITH GONADAL SPECIFICITY IN MICE
ALPHA-INHIBIN IS A TUMOR-SUPPRESSOR GENE WITH GONADAL SPECIFICITY IN MICE
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DOI：
10.1038/360313a0
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发表时间：
1992-11-26
期刊：
影响因子：
64.8
通讯作者：
BRADLEY, A
中科院分区：
文献类型：
--
作者：
MATZUK, MM;FINEGOLD, MJ;BRADLEY, A
所述α：β异源二聚体生长因子是转化生长因子-β家族的成员。为了了解α-glycoprotein在哺乳动物发育和生殖中的生理作用，通过在小鼠胚胎干细胞中同源重组产生α-glycoprotein基因的靶向缺失。空等位基因纯合子小鼠（Eschlobin缺陷型）最初发育正常，但每只小鼠最终都会单侧或双侧发生混合或不完全分化的性腺间质肿瘤。因此，抑制素是性腺基质细胞增殖的关键负调节因子，并且是第一个被鉴定为具有肿瘤抑制活性的分泌蛋白。
The inhibins are alpha:beta heterodimeric growth factors that are members of the transforming growth factor-beta family. To understand the physiological roles of the inhibins in mammalian development and reproduction, a targeted deletion of the alpha-inhibin gene was generated by homologous recombination in mouse embryonic stem cells. Mice homozygous for the null allele (inhibin-deficient) initially develop normally but every mouse ultimately develops mixed or incompletely differentiated gonadal stromal tumours either unilaterally or bilaterally. Inhibin is thus a critical negative regulator of gonadal stromal cell proliferation and the first secreted protein identified to have tumour-suppressor activity.