Surface modulatable nanocapsids for targeting and tracking toward nanotheranostic delivery
Surface modulatable nanocapsids for targeting and tracking toward nanotheranostic delivery
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DOI：
10.4155/ppa-2016-0021
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发表时间：
2016-01-01
影响因子：
1.3
通讯作者：
Cheng, R. Holland
中科院分区：
文献类型：
--
作者：
Stark, Marie;Cheng, R. Holland
纳米粒子诊断和治疗（纳米肿瘤学）在癌症检测和治疗方面具有显著的进步。然而，由于肿瘤定位和生物利用度的缺陷，许多纳米治疗无效。工程戊型肝炎病毒（HEV）纳米衣壳是一种靶向癌细胞递送的平台。纳米衣壳由HEV衣壳亚基自组装而成，保留了进入细胞并抵抗蛋白水解/酸性条件的能力，但缺乏感染性病毒成分。纳米衣壳表面经过化学活化修饰，以实现肿瘤特异性靶向和检测、免疫反应操纵和控制治疗递送。在体外组装过程中，纳米治疗分子可以被包装在中空的纳米衣壳中。作为对HEV衣壳适应性稳定性和细胞进入特性的补充，一种修饰的纳米衣壳可作为一种可调的肿瘤靶向平台，用于纳米声学递送。
Nanoparticle diagnostics and therapeutics (nanotheranostics) have significantly advanced cancer detection and treatment. However, many nanotheranostics are ineffective due to defects in tumor localization and bioavailability. An engineered Hepatitis E Virus (HEV) nanocapsid is a proposed platform for targeted cancer-cell delivery. Self-assembling from HEV capsid subunits, nanocapsids retain the capacity to enter cells and resist proteolytic/acidic conditions, but lack infectious viral elements. The nanocapsid surface was modified for chemical activation to confer tumor-specific targeting and detection, immune-response manipulation and controlled theranostic delivery. Nanotheranostic molecules can be packaged in the hollow nanocapsid shell during in vitro assembly. Complementing the adapted stability and cell-entry characteristics of the HEV capsid, a modified nanocapsid serves as a tunable tumor-targeting platform for nanotheronostic delivery.