Free radical pathology: inactivation of human alpha-1-proteinase inhibitor by products from the reaction of nitrogen dioxide with hydrogen peroxide and the etiology of emphysema.
Free radical pathology: inactivation of human alpha-1-proteinase inhibitor by products from the reaction of nitrogen dioxide with hydrogen peroxide and the etiology of emphysema.
复制标题
自由基病理学：二氧化氮与过氧化氢反应副产物人α-1-蛋白酶抑制剂的失活以及肺气肿的病因学。
DOI：
10.1016/0006-291x(82)91807-1
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发表时间：
1982
影响因子：
3.1
通讯作者：
Pryor,WA
中科院分区：
文献类型：
--
作者：
Dooley,MM;Pryor,WA
将人α-1-蛋白酶抑制剂暴露于75 ppm二氧化氮和1 mM过氧化氢，1小时后蛋白质的抗弹性蛋白酶活性损失65%。单独暴露在二氧化氮或过氧化氢中没有影响。当暴露期间包括甘露醇或超氧化物歧化酶时，抑制被部分阻止，这意味着在二氧化氮和过氧化氢之间的反应中形成超氧化物和羟基自由基，并在抑制过程中发挥作用。
Exposure of human α-1-proteinase inhibitor to 75 ppm nitrogen dioxide and 1 mM hydrogen peroxide results in a 65% loss in the anti-elastase activity of the protein after one hour. Exposure to either nitrogen dioxide or hydrogen peroxide alone has no effect. The inhibition is partially prevented when mannitol or superoxide dismutase is included during the exposure, implying that superoxide and the hydroxyl radical are formed in reactions between nitrogen dioxide and hydrogen peroxide and play a role in the inhibitory process.