Hypertension Enhances Advanced Atherosclerosis and Induces Cardiac Death in Watanabe Heritable Hyperlipidemic Rabbits
Hypertension Enhances Advanced Atherosclerosis and Induces Cardiac Death in Watanabe Heritable Hyperlipidemic Rabbits
复制标题
高血压会加剧渡边遗传性高脂血症兔的晚期动脉粥样硬化并导致心源性死亡
DOI：
10.1016/j.ajpath.2018.08.007
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发表时间：
2018-12-01
影响因子：
6
通讯作者：
Fan, Jianglin
中科院分区：
文献类型：
--
作者：
Ning, Bo;Chen, Yajie;Fan, Jianglin
高血压是动脉粥样硬化发展的主要危险因素。据报道，高血压病合并高血压患者的心血管风险显著增加。然而，尚不清楚高血压是否会直接破坏斑块的稳定性，从而增加心血管事件。为了研究高血压是否促进动脉粥样硬化的发展并增加斑块的脆弱性，我们通过手术切除一个肾脏和部分结扎另一个肾动脉来产生高血压渡边遗传性高血压病（WHHL）兔，并比较高血压WHHL兔与血压正常的WHHL兔的主动脉和冠状动脉粥样硬化的性质。所有高血压WHHL兔在术后34 ~ 56周死亡，而血压正常的WHHL兔无死亡。病理学检查显示，高血压WHHL兔出现不同程度的心肌梗死，冠脉严重狭窄沿着心肌肥厚。此外，高血压WHHL兔主动脉病变的斑块内出血和易损斑块的发生率高于正常血压WHHL兔。这些结果表明，在WHHL兔手术切除一个肾和部分结扎另一个肾动脉的方法诱导的高血压，不仅可以促进动脉粥样硬化的发展，而且也不稳定的斑块，增加心脏性死亡。
Hypertension is a major risk factor for the development of atherosclerosis. Cardiovascular risk has been reported to be significantly increased in hyperlipidemic patients with hypertension. However, it is not clear whether hypertension can directly destabilize plaques, thereby enhancing cardiovascular events. To examine whether hypertension enhances the development of atherosclerosis and increases plaque vulnerability, we generated hypertensive Watanabe heritable hyperlipidemic (WHHL) rabbits by surgical removal of one kidney and partial ligation of the other renal artery and compared the nature of aortic and coronary atherosclerosis in hypertensive WHHL rabbits with normotensive WHHL rabbits. All hypertensive WHHL rabbits died from 34 to 56 weeks after surgery, whereas no normotensive WHHL rabbits died. Pathologic examinations revealed that hypertensive WHHL rabbits showed different degrees of myocardial infarction caused by severe coronary stenosis along with myocardial hypertrophy. Furthermore, aortic lesions in hypertensive WHHL rabbits exhibited a higher frequency of intraplaque hemorrhage and vulnerable plaques than those in normotensive WHHL rabbits. These results indicate that hypertension induced by the surgical removal of one kidney and partial ligation of the other renal artery method in WHHL rabbits may not only enhance the development of atherosclerosis but also destabilize the plaques, increasing cardiac death.