Mechanisms of muscle atrophy and hypertrophy: implications in health and disease.
Mechanisms of muscle atrophy and hypertrophy: implications in health and disease.
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DOI：
10.1038/s41467-020-20123-1
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发表时间：
2021-01-12
影响因子：
16.6
通讯作者：
Sandri M
中科院分区：
文献类型：
--
作者：
Sartori R;Romanello V;Sandri M
骨骼肌是我们身体的蛋白质储存库，也是葡萄糖和脂质稳态的重要调节器。因此，肌肉量的增长或减少会影响一般的新陈代谢、运动、饮食和呼吸。因此，毫不奇怪，过度的肌肉损失是各种疾病的不良预后指标，包括癌症、器官衰竭、感染和不健康的衰老。肌肉功能受调节收缩蛋白和细胞器功能的不同质量系统的影响。这些系统由转录依赖程序控制，使肌肉细胞适应环境和营养线索。机械、氧化、营养和能量应激，以及生长因子或细胞因子调节信号通路，最终汇聚于蛋白质和细胞器的更新。控制和协调这种复杂网络的新见解不断涌现，并将在本综述中进行总结。了解控制肌肉质量的机制将为治疗遗传性和非遗传性疾病的肌肉损失以及改善衰老过程中的生活质量提供治疗靶点。肌肉量的减少与衰老和癌症等许多疾病有关。在这里，作者回顾了调节蛋白质合成和降解以及肌肉质量增加或减少的信号通路，并讨论了该领域的治疗意义和未来方向。
Skeletal muscle is the protein reservoir of our body and an important regulator of glucose and lipid homeostasis. Consequently, the growth or the loss of muscle mass can influence general metabolism, locomotion, eating and respiration. Therefore, it is not surprising that excessive muscle loss is a bad prognostic index of a variety of diseases ranging from cancer, organ failure, infections and unhealthy ageing. Muscle function is influenced by different quality systems that regulate the function of contractile proteins and organelles. These systems are controlled by transcriptional dependent programs that adapt muscle cells to environmental and nutritional clues. Mechanical, oxidative, nutritional and energy stresses, as well as growth factors or cytokines modulate signaling pathways that, ultimately, converge on protein and organelle turnover. Novel insights that control and orchestrate such complex network are continuously emerging and will be summarized in this review. Understanding the mechanisms that control muscle mass will provide therapeutic targets for the treatment of muscle loss in inherited and non-hereditary diseases and for the improvement of the quality of life during ageing. Loss of muscle mass is associated with ageing and with a number of diseases such as cancer. Here, the authors review the signaling pathways that modulate protein synthesis and degradation and gain or loss of muscle mass, and discuss therapeutic implications and future directions for the field.
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影响因子：
8.8
作者：
Carnio S;LoVerso F;Baraibar MA;Longa E;Khan MM;Maffei M;Reischl M;Canepari M;Loefler S;Kern H;Blaauw B;Friguet B;Bottinelli R;Rudolf R;Sandri M
通讯作者：
Sandri M
影响因子：
8.9
作者：
Adams, Volker;Bowen, T. Scott;Labeit, Siegfried
通讯作者：
Labeit, Siegfried
影响因子：
5.3
作者：
Bohnert, Kyle R.;Goli, Praneeth;Kumar, Ashok
通讯作者：
Kumar, Ashok
影响因子：
8
作者：
Davey, Jonathan R.;Watt, Kevin I.;Gregorevic, Paul
通讯作者：
Gregorevic, Paul
DOI：
10.1083/jcb.201110067
发表时间：
2012-08-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cohen S;Zhai B;Gygi SP;Goldberg AL
通讯作者：
Goldberg AL