ALLODYNIA EVOKED BY INTRATHECAL ADMINISTRATION OF PROSTAGLANDIN-F2-ALPHA TO CONSCIOUS MICE
ALLODYNIA EVOKED BY INTRATHECAL ADMINISTRATION OF PROSTAGLANDIN-F2-ALPHA TO CONSCIOUS MICE
复制标题
DOI：
10.1016/0304-3959(92)90166-9
复制
发表时间：
1992-08-01
期刊：
影响因子：
7.4
通讯作者：
HAYAISHI, O
中科院分区：
文献类型：
--
作者：
MINAMI, T;UDA, R;HAYAISHI, O
The intrathecal administration of prostaglandin F2-alpha to conscious mice resulted in spontaneous agitation and touch-evoked agitation (allodynia) in the animals. The maximum allodynia induced by prostaglandin F2-alpha was observed at 10-15 min after intrathecal injection, and the response did not disappear by 120 min. Prostaglandin F2-alpha produced allodynia over a wide range of dosage from 0.1 pg to 2.5-mu-g/mouse. Dose dependency of prostaglandin F2-alpha for allodynia showed a skewed bell-shaped pattern, and the maximal allodynic effect was observed at 1.0-mu-g. This allodynia was dose-dependently relieved by alpha-1-adrenergic (methoxamine), alpha-2-adrenergic (clonidine), and A1-adenosine (RPIA) agonists. Clonidine was 1.5 orders of magnitude more potent than methoxamine in blocking prostaglandin F2-alpha-induced allodynia. The blockade by clonidine was dose-dependently reversed by the alpha-2-adrenergic antagonist yohimbine but not by the alpha-1-adrenergic antagonist prazosin. These results demonstrate that prostaglandin F2-alpha administered intrathecally induces allodynia in conscious mice and that the allodynia involves the alpha-2-adrenergic and A1-adenosine systems. Because this allodynia has a clear resemblance to the characteristics of chronic pain in patients with causalgia and reflex sympathetic dystrophy, prostaglandin F2-alpha may be involved in allodynia observed with these disorders.
