Serum calprotectin--a promising diagnostic marker for adult-onset Still's disease.
Serum calprotectin--a promising diagnostic marker for adult-onset Still's disease.
复制标题
血清钙卫蛋白——一种有前景的成人斯蒂尔病诊断标志物
DOI：
10.1007/s10067-015-3108-6
复制
发表时间：
2016-01
影响因子：
3.4
通讯作者：
Su Y
中科院分区：
文献类型：
--
作者：
Guo Q;Zha X;Li C;Jia Y;Zhu L;Guo J;Su Y
钙保护素是一种钙结合胞浆蛋白，主要表达于免疫细胞，如中性粒细胞、单核细胞和巨噬细胞。本研究旨在通过比较成人斯蒂尔病(n = 46例)、类风湿关节炎(RA，n = 34例)、原发性干燥综合征(pss，n = 40例)、系统性红斑狼疮(n = 39例)、骨性关节炎(OA，n = 20例)和健康对照(n = 49例)患者血清钙保护素水平，评价其对成人斯蒂尔病的诊断价值。AOSD患者血清钙保护素水平(55.26 ± 18.00 ng/ml)明显高于RA(39.17 ± 18.90 ng/ml)、PSS(35.31 ± 19.47 ng/ml)、系统性红斑狼疮(32.21 ± 25.01 ng/ml)、骨性关节炎(19.24 ± 10.67 ng/ml)和肥厚性骨质疏松症(8.46 ± 5.17 ng/ml)。所有差异均极显著(p <； 0.001)。根据受试者-操作特征曲线，确定钙保护素的临界值为45.488 ng/ml，其诊断AOSD的敏感度和特异度分别为63.0%和80.1%。与其他疾病患者和健康对照组相比，急性阻塞性肺疾病患者钙保护素的阳性率显著升高(p <； 0.001)。血清钙化保护素与铁蛋白呈正相关(r = 0.294，p <； 0.294)，且钙化保护素阳性组的血红蛋白浓度显著低于阴性组(103.49 ± 20.21g/L vs 115.71 ± 15.59g/L，t = −2.142，p = 0.038)。提示血清钙保护素可作为AOSD的诊断指标，并在一定程度上监测病情活动性。
Calprotectin is a calcium-binding cytosolic protein, mainly expressed in immune cells, such as neutrophils, monocytes, and macrophages. Our study aimed to evaluate the diagnostic value of calprotectin for adult-onset Still’s disease (AOSD), by comparing serum calprotectin concentrations in patients with AOSD (n = 46), rheumatoid arthritis (RA, n = 34), primary Sjögren syndrome (pSS, n = 40), systemic lupus erythematosus (SLE, n = 39), osteoarthritis (OA, n = 20), and healthy controls (HCs, n = 49). Calprotectin concentrations were significantly higher in patients with AOSD (55.26 ± 18.00 ng/ml), compared to patients with RA (39.17 ± 18.90 ng/ml), pSS (35.31 ± 19.47 ng/ml), SLE (32.21 ± 25.01 ng/ml), OA (19.24 ± 10.67 ng/ml), and HCs (8.46 ± 5.17 ng/ml). All the differences were highly significant (p < 0.001). Using receiver-operating characteristic curve, the cut-off value of calprotectin was defined as 45.488 ng/ml, and its sensitivity and specificity for AOSD diagnosis were 63.0 and 80.1 %, respectively. The positive rate of calprotectin was significantly higher in AOSD cases compared to patients with other diseases and healthy controls (p < 0.001). Serum calprotectin was positively correlated with ferritin (r = 0.294, p < 0.05), and concentration of hemoglobin was significantly lower in calprotectin-positive patients compared to negative patients in AOSD (103.49 ± 20.21 g/l vs 115.71 ± 15.59 g/l, t = −2.142, p = 0.038). These findings suggest that serum calprotectin may serve as a promising marker for the diagnosis of AOSD and monitor disease activity to a certain extent.