Clinical and aetiological aspects in urticaria and angio-oedema
Clinical and aetiological aspects in urticaria and angio-oedema
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荨麻疹和血管性水肿的临床和病因学方面
DOI：
10.1046/j.1365-2133.2003.05169.x
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发表时间：
2003
影响因子：
10.3
通讯作者：
A. Tursi
中科院分区：
文献类型：
--
作者：
E. Nettis;A. Pannofino;C. D'Aprile;A. Ferrannini;A. Tursi
背景荨麻疹是一种常见的疾病，影响多达20%的人在某些时候在他们的一生。
目的分析流行的各种形式的荨麻疹的病因和临床分类，我们进行了为期4年的研究，在门诊诊所。
方法对562例因荨麻疹和血管性水肿就诊的患者（男178例，女384例，平均年龄35.4 ± 16岁）进行研究。基线研究包括：患者的家族和个人过敏史;症状持续时间、相关症状的存在和当前发作的客观体征;临床、实验室和仪器检查;抗组胺治疗反应的评估。
结果35%的患者有家族过敏史，24%的患者有个人过敏史。我们将荨麻疹和血管性水肿根据其临床和病因学方面分为几组。在562例患者中，424例（76%）表现为普通荨麻疹（43例急性荨麻疹，311例慢性荨麻疹，70例阵发性荨麻疹），80例（14%）表现为物理性荨麻疹，49例（9%）表现为无伤口的血管性水肿，6例（1%）表现为IgE介导的接触性荨麻疹，3例（0.5%）表现为荨麻疹性血管炎。在64例病例（11%）中，荨麻疹/血管性水肿与一种或多种症状相关。我们确定了394例（82%）特发性荨麻疹，42例（9%）免疫性荨麻疹，29例（6%）非免疫性荨麻疹和17例（3%）继发于感染的荨麻疹。在接受治疗的受试者中，54%显示对抗组胺药治疗的良好反应。
结论我们的数据提供了一个概述荨麻疹/血管性水肿在一个大系列的患者，根据临床病因方面，并与最近的诊断指南。
SummaryBackground Urticaria is a common disorder that affects as many as 20% of all people at some time during their lifetime.
Objectives To analyse the prevalence of various forms of urticaria according to an aetiological and clinical classification, we carried out a 4-year study in an outpatient clinic.
Methods The study was carried out on 562 consecutive patients (178 males and 384 females; mean age 35·4 ± 16), who had been referred to our unit for the study of urticaria and angio-oedema. Baseline investigations included: the patient's family and personal history of allergy; duration of symptoms, presence of associated symptoms and objective signs of the current episode; clinical, laboratory and instrumental investigations; assessment of response to antihistamine treatment.
Results A family history of atopy was present in 35% of patients and a personal history of allergy in 24%. We subdivided urticaria and angio-oedema into several groups on the basis of their clinical and aetiological aspects. Of the 562 patients, 424 (76%) presented with ordinary urticaria (43 acute urticaria, 311 chronic urticaria, 70 episodic urticaria), 80 (14%) physical urticaria, 49 (9%) angio-oedema without weals, six (1%) IgE-mediated contact urticaria and three (0·5%) urticarial vasculitis. In 64 cases (11%) urticaria/angio-oedema was associated with one or more symptoms. We identified 394 cases (82%) of idiopathic urticaria, 42 (9%) of immunological urticaria, 29 (6%) of non-immunological urticaria and 17 (3%) of urticaria secondary to infections. Of the treated subjects, 54% showed a good response to treatment with antihistamines.
Conclusions Our data provide an overview of urticaria/angio-oedema in a large series of patients, based on clinical–aetiological aspects, and related to recent diagnostic guidelines.