Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia?: Results of the EPIPAGE cohort study
Are maternal hypertension and small-for-gestational age risk factors for severe intraventricular hemorrhage and cystic periventricular leukomalacia?: Results of the EPIPAGE cohort study
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DOI：
10.1016/j.ajog.2004.11.057
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发表时间：
2005-07-01
影响因子：
9.8
通讯作者：
Kaminski, M
中科院分区：
文献类型：
--
作者：
Ancel, PY;Marret, S;Kaminski, M
目的：本研究的目的是探讨早产的不同原因（例如，孕产妇高血压、小于胎龄 [SGA] 等）与脑损伤（例如，囊性脑室周围白质软化 [c-PVL]、III 级脑室内出血 [IVH] 和脑实质内出血 [IPH]）之间的关系。 研究设计：本研究纳入了 1902 名极早产单胎，他们被转移到法国 9 个地区的新生儿重症监护室。我们使用逻辑回归模型来比较风险。结果：我们发现，短潜伏期胎膜早破（PPROM）或特发性早产后出生的婴儿发生 c-PVL 和 III 级 IVH 的风险高于高血压母亲所生的婴儿。我们发现，SGA和产前产妇出血会显着增加IPH的风险。结论：我们的研究结果表明，高血压母亲所生的婴儿比特发性早产和未足月胎膜早破所生的婴儿发生脑损伤的风险较低，因为他们较少受到产前感染。 (c) 2005 Elsevier Inc. 保留所有权利。
Objective: The purpose of this study was to examine the relationships between different causes of preterm delivery (eg, maternal hypertension, small-for-gestational age [SGA], other) and cerebral damage (eg, cystic periventricular leukomalacia [c-PVL], grade III intraventricular hemorrhage [IVH], and intra-parenchymal hemorrhage [IPH]).Study design: This study included 1902 very preterm singletons who were transferred to neonatal intensive care units in 9 French regions. We used logistic regression models to compare the risk of. cerebral injury associated with maternal hypertension, SGA, and all other causes of preterm delivery.Results: We found that the risk of c-PVL and grade III IVH was higher in infants born after preterm premature rupture of membranes (PPROM) with short latency or idiopathic preterm labor than in infants born to hypertensive mothers. We show that SGA and antepartum maternal hemorrhage significantly increase the risk of IPH.Conclusion: Our results show that infants born to hypertensive mothers have a lower risk of cerebral injuries than infants born following idiopathic preterm labor and PPROM because they are less exposed to prenatal infection. (c) 2005 Elsevier Inc. All rights reserved.