Adaptive control of brain temperature for brain hypothermia treatment using Stolwijk-Hardy model
Adaptive control of brain temperature for brain hypothermia treatment using Stolwijk-Hardy model
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DOI：
10.1007/s10015-004-0310-z
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发表时间：
2004-12
影响因子：
0.9
通讯作者：
H. Wakamatsu;L. Gaohua
中科院分区：
文献类型：
--
作者：
H. Wakamatsu;L. Gaohua
提出了一种用于脑损伤和炎症治疗的自动热控制系统。该系统基于参考模型自适应控制方法。它根据个体之间的差异，以及患者生理状态的慢性变化和环境条件的变化，自适应地工作。使用Stolwijk-Hardy模型的人体热系统，大脑温度与头部、躯干和四肢的环境温度及其代谢产热动态相关。模拟实验检测了不同物理条件下脑温度的动态特征，为临床脑降温治疗提供了更好的认识，同时也为模型的有效性提供了良好的证据。脑温度是根据各种临床经验提示的适当生理状态进行自适应控制的。这种自适应控制系统可用于在严重损伤或炎症脑中实施自动低温控制。
An automatic thermal control system is proposed for the treatment of cerebral injury and inflammation. The system is based on the reference model adaptive control method. It works adaptively according to the difference between individuals, and chronic change of the patient’s physiological state, and changes in the environmental conditions. Using the human thermal system of the Stolwijk-Hardy model, the brain temperature is dynamically related to the ambient temperature of the head, trunk, and extremities and their metabolic heat production. The dynamic characteristics of brain temperature under various physical conditions, as examined by simulation experiments, provide improved understanding of clinical brain cooling treatment, which simultaneously give good evidence for the validity of the model. The brain temperature is adaptively controlled in accordance with the appropriate physiological state suggested by various clinical experiences. This kind of adaptive control system is useful for the practical implementation of automatic hypothermia control in seriously injured or inflamed brain.