Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod
Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod
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DOI：
10.1098/rspb.2016.2780
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发表时间：
2017-05
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影响因子：
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通讯作者：
Frank J. Tulenko;James L. Massey;E. Holmquist;Gabriel Kigundu;Sarah Thomas;Susan M E Smith;S. Mazan;Marcus C. Davis
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文献类型：
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作者：
Frank J. Tulenko;James L. Massey;E. Holmquist;Gabriel Kigundu;Sarah Thomas;Susan M E Smith;S. Mazan;Marcus C. Davis
Autopod的进化起源涉及丢失鳍折和相关的皮肤骨架，并随着远端内骨骼的详细说明，形成腕部和数字。发展研究主要来自硬骨植物和羊膜，提出了一个附属物进化的模型，在这种模型中，通过延长AER介导的调节网络的功能，通过延迟了AER至fin折叠式转化为燃料内骨骼扩张。在这里，我们表征了Paddlefish Polyodon Spathula（非静脉肌动症）和Catshark Scyliorhinus Canicula（Chondrichthyan）中配对的FIN发育方面的各个方面，以在更广泛的系统生理环境中探索该模型的各个方面。我们的数据表明，在基底gnathostomes中，自动脚架标记HOXA13与皮肤骨骼组件共定位，1和1标记鳍折的位置，支持最近的工作，证明了Hoxa13在Zebrafish Fin Ray开发中的作用。此外，我们表明，在paddlefish中，近端鳍和鳍折中质具有共同的中胚层，并且SHH/lim/lim/lim/gremlin/fgf转录网络的成分对肢体芽芽产生至关重要的转录网络在鳍片中表达，并表达了类似于Tetrapods的曲线。这些数据加在一起与AER杂音的假设形成了鲜明的对比，并表明肢体特异性的形态是通过在保守的早期远端图案隔室的分化结果中的进化变化而产生的。
The evolutionary origin of the autopod involved a loss of the fin-fold and associated dermal skeleton with a concomitant elaboration of the distal endoskeleton to form a wrist and digits. Developmental studies, primarily from teleosts and amniotes, suggest a model for appendage evolution in which a delay in the AER-to-fin-fold conversion fuelled endoskeletal expansion by prolonging the function of AER-mediated regulatory networks. Here, we characterize aspects of paired fin development in the paddlefish Polyodon spathula (a non-teleost actinopterygian) and catshark Scyliorhinus canicula (chondrichthyan) to explore aspects of this model in a broader phylogenetic context. Our data demonstrate that in basal gnathostomes, the autopod marker HoxA13 co-localizes with the dermoskeleton component And1 to mark the position of the fin-fold, supporting recent work demonstrating a role for HoxA13 in zebrafish fin ray development. Additionally, we show that in paddlefish, the proximal fin and fin-fold mesenchyme share a common mesodermal origin, and that components of the Shh/LIM/Gremlin/Fgf transcriptional network critical to limb bud outgrowth and patterning are expressed in the fin-fold with a profile similar to that of tetrapods. Together these data draw contrast with hypotheses of AER heterochrony and suggest that limb-specific morphologies arose through evolutionary changes in the differentiation outcome of conserved early distal patterning compartments.