Parametric study of irreversible electroporation with different needle electrodes: Electrical and thermal analysis
Parametric study of irreversible electroporation with different needle electrodes: Electrical and thermal analysis
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DOI：
10.3109/02656736.2014.937775
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发表时间：
2014-08-01
影响因子：
3.1
通讯作者：
Firoozabadi, S. Mohammad P.
中科院分区：
文献类型：
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作者：
Nickfarjam, Abolfazl;Firoozabadi, S. Mohammad P.
目的：不可逆电穿孔(IRE)是一种用于肿瘤治疗的新型肿瘤消融方法。在成功的IRE治疗中，对肿瘤及其周围的健康组织施加最小的热损害是至关重要的，同时使整个肿瘤受到强大的电场。方法：在这里，我们提出了一个四层皮肤中的皮下肿瘤的3D模型，使用基于几何的有限元方法。本文研究了四种常见的针状电极结构。这项研究评估了在肿瘤和正常组织中的电和热分布中重要的六个基本因素。结果：结果显示，与其他电极配置相比，六角形的3x3几何结构提供了最大的肿瘤电覆盖率。然而，在某些情况下，六角形的2x2几何结构可以在对正常组织损害较小的情况下消融整个肿瘤。我们发现，2-和4-电极几何形状的插入越深，可能会对健康组织造成更大的损害。结果还表明，由于存在较大的导电性，将电极插入肿瘤组织会显著增加热损伤。结论：这些发现表明，如果目标是防止热损伤，针电极不应放置在肿瘤组织内。这种方法可以在肿瘤组织的电场覆盖和对肿瘤和正常组织的热损伤之间进行权衡。
Purpose: Irreversible electroporation (IRE) is a new tumour ablation method used in cancer treatment procedures. In a successful IRE treatment it is crucial to impose minimum thermal damage to the tumour and its surrounding healthy tissue, while subjecting the entire tumour to a strong electric field. Method: Here we present a 3D model of a subcutaneous tumour in a four-layer skin using a geometry-based finite element approach. Four common needle electrode configurations were studied in this paper. The study evaluated six essential factors which are important in the electrical and thermal distributions in tumour and normal tissue. Results: The results revealed that a hexagonal 3 x 3 geometry provides the maximum electrical coverage of the tumour, compared to other electrode configurations. However, in some cases the hexagonal 2 x 2 geometry can ablate the entire tumour with less damage to normal tissue. We found that the deeper insertion of 2- and 4-electrode geometries can lead to more damage to healthy tissue. The results also indicate that the insertion of the electrodes into tumour tissue can increase thermal damage dramatically due to existing large electrical conductivity. Conclusion: These findings suggest that needle electrodes should not be placed within the tumour tissue if the goal is to prevent thermal damage. This method can be used as a trade-off between electric field coverage in tumour tissue and thermal damage to both tumour and normal tissue.