GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP binding proteins
GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP binding proteins
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DOI：
10.1016/s0959-440x(97)80147-9
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发表时间：
1997-12-01
影响因子：
6.8
通讯作者：
Wittinghofer, A
中科院分区：
文献类型：
--
作者：
Geyer, M;Wittinghofer, A
细胞生物学依赖于大分子之间的相互作用，如蛋白质-DNA、蛋白质-蛋白质或蛋白质-核苷酸相互作用。GTP结合蛋白也不例外。它们调节蛋白质生物合成和细胞内膜运输等多种细胞过程。近年来，大量编码GTP结合蛋白和与这些分子开关相互作用的蛋白的基因被克隆和表达。其中一些的3D结构也得到了阐明。(C)Current Biology Ltd ISSN 0959-440X。
Cell biology depends on the interactions of macromolecules, such as protein-DNA, protein-protein or protein-nucleotide interactions. GTP-binding proteins are no exception to the rule. They regulate cellular processes as diverse as protein biosynthesis and intracellular membrane trafficking. Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated. (C) Current Biology Ltd ISSN 0959-440X.