Fluid dynamics of gas exchange in high-frequency oscillatory ventilation: In vitro investigations in idealized and anatomically realistic airway bifurcation models
Fluid dynamics of gas exchange in high-frequency oscillatory ventilation: In vitro investigations in idealized and anatomically realistic airway bifurcation models
复制标题
DOI：
10.1007/s10439-008-9557-1
复制
发表时间：
2008-11-01
影响因子：
3.8
通讯作者：
Quinlan, Nathan J.
中科院分区：
文献类型：
--
作者：
Heraty, Kevin B.;Laffey, John G.;Quinlan, Nathan J.
这项工作的目的是加深对高频振荡通风(HFOV)中气体交换的局部流体动力学机制的理解。利用粒子图像测速仪，在理想和真实的单分叉模型中，对HFOV过程中的流场进行了实验研究。结果表明，在气流反转时，吸气和呼气两股流体在气道中共存，二次流和与剪切层相关的涡流加强了吸气和呼气两股流体的混合。非定常流分离和再循环发生在两种几何形状中。实际模型中的二次流比理想模型中的二次流大，二次流的结构也有很大的不同。然而，其他流动结构在性质上是相似的。
The objective of this work is to develop understanding of the local fluid dynamic mechanisms that underpin gas exchange in high-frequency oscillatory ventilation (HFOV). The flow field during HFOV was investigated experimentally using particle image velocimetry in idealized and realistic models of a single bifurcation. Results show that inspiratory and expiratory fluid streams coexist in the airway at flow reversal, and mixing between them is enhanced by secondary flow and by vortices associated with shear layers. Unsteady flow separation and recirculation occurs in both geometries. The magnitude of secondary flow is greater in the realistic model than in the idealized model, and the structure of secondary flow is quite different. However, other flow structures are qualitatively similar.