Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex.
Enhanced serological and virological findings of Epstein-Barr virus in patients with AIDS and AIDS-related complex.
复制标题
艾滋病和艾滋病相关综合症患者中 Epstein-Barr 病毒的血清学和病毒学研究结果得到增强。
DOI：
10.1093/infdis/154.5.864
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Mansell,PW
中科院分区：
文献类型：
--
作者：
Sumaya,CV;Boswell,RN;Ench,Y;Kisner,DL;Hersh,EM;Reuben,JM;Mansell,PW
The potential involvement of Epstein-Barr virus (EBV) in AIDS was examined by determining the type of EBV-specific antibody responses and the EBV content or lymphoproliferative ability present in selected body fluids of patients with AIDS or AIDS-related complex. The results were compared with two control groups. An enhanced antibody response to a broad spectrum of EBV antigens was found in patients with AIDS or AIDS-related complex. The pattern of virus-specific antibody responses resembled that associated with a persistent or reactivated infection. The content of EBV in oropharyngeal secretions and the lymphoproliferative ability in peripheral blood from patients with AIDS or AIDSrelated complex was significantly greater than that from healthy controls and approached levels detected in the control group with infectious mononucleosis. These findings, together with recent reports of cellular-level interaction between EBV and human T lymphotropic virus type III, suggest that EBV may have a contributory role in these disorders.
