Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia
Activation of lamina I spinal cord neurons that express the substance P receptor in visceral nociception and hyperalgesia
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DOI：
10.1054/jpai.2002.27001
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发表时间：
2002-02-01
期刊：
影响因子：
4
通讯作者：
Mantyh, PW
中科院分区：
文献类型：
--
作者：
Honoré, P;Kamp, EH;Mantyh, PW
表达P物质受体（SPR）的脊髓I层神经元已被证明在躯体炎性疼痛和神经病理性疼痛的传递中起作用。为了评估他们参与内脏伤害性感受在两个noninflamed和发炎的结肠，我们研究了SPR的表达和配体诱导的内在化在大鼠脊髓扩张后的noninflamed结肠和大鼠结肠内滴注酵母多糖（3小时）引起的炎症。在非炎症动物中，急性有害性而非有害性结肠直肠扩张在胸腰段（T13）和腰骶段（S1）脊髓水平的I层神经元中诱导SPIR内化，而在脊髓腰段L4的I层神经元中未检测到SPR内化。虽然酵母多糖诱导的结直肠炎症单独不诱导SPR内化在板层I神经元，有SPR表达板层I神经元的数量增加，显示SPR内化在节段T12通过S2的脊髓结直肠扩张后。这些结果表明，急性伤害性内脏刺激诱导激活脊髓I层神经元表达的SPR和，内脏炎症后，有一个显着的增加：数量和吻尾侧范围的板I SPR神经元激活响应正常非伤害性和伤害性扩张的结肠。(C)2002年，美国疼痛协会。
Spinal lamina I neurons expressing the: substance P receptor (SPR) have been shown to play a role in the transmission of somatic inflammatory and neuropathic pain. To evaluate their involvement in visceral nociception in both the noninflamed and inflamed colon, we examined the expression and ligand-induced internalization of the SPR in the rat spinal cord after distention of the noninflamed colon and in rats with inflammation induced by intracolonic instillation of zymosan (3 hours). in the noninflamed animal, acute noxious but not non-noxious colorectal distention induced SPIR internalization in lamina I neurons at the thoracolumbar (T13) and lumbosacral (S1) spinal levels, whereas SPR internalization was not detected in lamina I neurons at spinal lumbar segment L4. Although zymosan-induced colorectal inflammation alone did not induce SPR internalization in lamina I neurons, there was an increased number of SPR-expressing lamina I neurons showing SPR internalization in segments T12 through S2 of the spinal cord after colorectal distention. These results show that acute noxious visceral stimuli induce activation of spinal lamina I neurons expressing the SPR and, that after visceral inflammation, there is a marked increase in both the: number and rostro-caudal extent of lamina I SPR neurons activated in response to both normally non-noxious and noxious distention of the colon. (C) 2002 by the American Pain Society.