DROSOPHILA GENES WHICH INTERVENE IN MULTIPLICATION OF SIGMA VIRUS
DROSOPHILA GENES WHICH INTERVENE IN MULTIPLICATION OF SIGMA VIRUS
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DOI：
10.1007/bf00268263
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发表时间：
1978-01-01
期刊：
影响因子：
--
通讯作者：
GAY, P
中科院分区：
文献类型：
--
作者：
GAY, P
果蝇品系之间的区别，不同的能力，支持西格玛病毒的增殖，从接种病毒悬浮液后的孵育时间的比较。这是最普遍和最有用的特征。结果表明，与果蝇参考品系俄勒冈州相比，有5个等位基因存在差异，对应的基因ref（1）H，ref（2）M，ref（2）P，ref（3）O和ref（3）D分布于果蝇染色体上。确定了每个基因对一个或另一个等位基因敏感的病毒株的特异性谱。作用于孵育时间的基因的2个等位基因中的每一个的纯合子在分化细胞类型特异性的一种性质上可能没有差异，这仅仅是因为所考虑的基因在所涉及的细胞类型中不表达。相反地，也可能存在对这种性质起作用而对孵化时间不起作用的基因。可能已经发现了这样一个基因;它通过稳定的雄性来干预西格玛病毒的传播;该基因被命名为ref（3）V。Ref（1）H、ref（2）M、ref（2）P、ref（3）D和可能的ref（3）V基因（如果最后一个基因直接干预西格玛的生理学）涉及复制所必需的功能。没有发现参考文献（3）O的确凿证据，但它似乎仍然干预晚期功能。前5个ref基因的产物之间的功能相互作用的问题已经被提及。
Distinction between Drosophila strains, differing in their capacity for supporting multiplication of sigma virus, arises from comparison of the incubation time after inoculation of a viral suspension. This is the most general and the most useful characteristic. By this mean 5 allelic differences with the reference Drosophila strain Oregon have been found. Corresponding genes, ref(1)H, ref(2)M, ref(2)P, ref(3)O and ref(3)D are located all over Drosophila chromosomes. The specific spectra of viral strains sensitive to the one or the other allele was determined for each gene. Homozygotes for each of the 2 alleles of a gene which acts on incubation time can show no difference in one property which is specific of a differentiated cell type only because the considered gene is not expressed in the cell type involved. Conversely, genes can exist which act on such a property and which have no action on incubation time. Probably such a gene has been discovered; it intervenes in the transmission of sigma virus by stabilized males; this gene is named ref(3)V. Ref(1)H, ref(2)M, ref(2)P, ref(3)D and possibly ref(3)V genes (if this last gene intervenes directly in sigma''s physiology) are involved in a function necessary for replication. No conclusive evidence has been found for ref(3)O, still it seems to intervene in a late function. Problems of functional interactions between products of the first 5 ref genes have been mentioned.