2 NEW INBRED RAT STRAINS DERIVED FROM SHR - WKHA, HYPERACTIVE, AND WKHT, HYPERTENSIVE, RATS
2 NEW INBRED RAT STRAINS DERIVED FROM SHR - WKHA, HYPERACTIVE, AND WKHT, HYPERTENSIVE, RATS
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DOI：
10.1152/ajpheart.1991.261.2.h583
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发表时间：
1991-08-01
影响因子：
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通讯作者：
OHLSSON, WG
中科院分区：
文献类型：
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作者：
HENDLEY, ED;OHLSSON, WG
已经培育出两种新的近交系大鼠。一个是WKHA，表现出多动症，另一个是WKHT，表现出高血压。这两种特性在SHR中都有表达。通过将自发性高血压大鼠（SHR）与Wistar-Kyoto（WKY）对照大鼠杂交，然后进行重组选择近交，我们成功地在两个新品系中从高血压中遗传分离了多动。纵向研究表明，在WKHT中持续存在高血压而无多动，在WKHA中持续存在多动而无高血压，至少超过1年。心室扩大，SHR的另一个特点，观察成年WKHTs高血压发作后，然而，心室已经扩大在血压正常的WKHA在6周。WKHA的紧急行为特征表明，他们保留了多动特征和对压力的高反应性，而不是SHR的一些其他行为，如不良习惯。对WKHTs的研究表明，作为遗传性高血压的模型，它们比SHR有所改善，因为它们缺乏一些突出的行为异常。然而，四个遗传相关的菌株（WKHA，WKHT，SHR和WKY），一起使用，被认为是最合适的寻求生物差异与高血压或多动症的相关性。
Two new strains of inbred rats have been developed. One, WKHA, exhibits hyperactivity, and the other, WKHT, exhibits hypertension. Both of these traits are expressed in the SHR. By crossing spontaneously hypertensive rats (SHRs) with Wistar-Kyoto (WKY) controls, followed by recombinant selected inbreeding, we succeeded in genetically separating the hyperactivity from the hypertension in two new strains. Longitudinal studies indicate a persistence of hypertension without hyperactivity in WKHTs, and hyperactivity without hypertension in WKHAs, over at least 1 year. Ventricular enlargement, another characteristic of SHRs, was observed in adult WKHTs after the onset of hypertension; however, ventricles were already enlarged in normotensive WKHAs at 6 wk. The emergent behavioral profile of WKHAs indicates that they retain the hyperactivity trait and hyper-reactivity to stress, and not some of the other behaviors of SHRs, such as poor habituation. Studies in WKHTs suggest that they are an improvement over SHRs as a model of genetic hypertension as they lack some prominent behavioral abnormalities. Nevertheless, the four genetically related strains (WKHA, WKHT, SHR, and WKY), used together, are considered most appropriate for seeking correlations of biological differences with either hypertension or hyperactivity.