Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation
Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation
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DOI：
10.1097/00007890-200104150-00011
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发表时间：
2001-04-15
期刊：
影响因子：
6.2
通讯作者：
Rose, ML
中科院分区：
文献类型：
--
作者：
Jurcevic, S;Ainsworth, ME;Rose, ML
背景。移植相关性冠状动脉疾病（TxCAD）是心脏移植术后最严重的长期并发症。抗内皮抗体与疾病有关，在患者血清中识别的主要内皮抗原之一已被证明是蛋白丝静脉蛋白。在这项研究中，我们研究了抗vimentin抗体是否与TxCAD相关，以及它们的存在是否可以用于识别血管造影可检测到TxCAD的高危患者。移植后5年，从109例患者中回顾性收集880份序列血清（7.07+/-1.8份/例）；大多数是在头两年收集的。采用ELISA法检测血清抗vimentin抗体。通过年度血管造影评估TxCAD。在发生TxCAD的患者中，抗vimentin抗体的平均滴度，计算到1年、2年和5年，显著高于那些没有疾病的患者(P
Background. Transplant-associated coronary artery disease (TxCAD) is the most serious long-term complication after cardiac transplantation. Anti-endothelial antibodies are associated with disease, and one of the major endothelial antigens recognized in the sera of patients has been shown to be the protein filament vimentin. In this study, we investigated whether antivimentin antibodies are associated with TxCAD and whether their presence can be used to identify patients at high risk of developing angiographically detectable TxCAD.Methods. Up to 5 years after transplantation, 880 sequential sera (7.07+/-1.8 samples/patient) were collected retrospectively from 109 patients; the majority were collected in the first 2 years. Sera were assessed for antivimentin antibodies using ELISA. TxCAD was assessed by annual angiography.Results. Mean titres of antivimentin antibodies, calculated up to 1, 2, and 5 years, were significantly higher in patients who developed TxCAD than those who remained disease free (P