Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia
Neuroendocrine and cytokine profile of chronic mild stress-induced anhedonia
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DOI：
10.1016/j.physbeh.2005.02.011
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发表时间：
2005-04-13
影响因子：
2.9
通讯作者：
Johnson, AK
中科院分区：
文献类型：
--
作者：
Grippo, AJ;Francis, J;Johnson, AK
抑郁症与心血管疾病之间存在双向关系。重度抑郁症患者更容易发生心脏事件，心肌梗死和心力衰竭患者更容易发生抑郁症。两种临床综合征的共同特征是促炎细胞因子和应激激素的激活，包括下丘脑-垂体-肾上腺轴和肾素-血管紧张素-醛固酮系统。在本研究中，我们研究的假设，暴露于慢性轻度应激（CMS），抑郁症的实验模型，诱导大鼠快感缺失，足以激活生产的促炎细胞因子和应激激素，是有害的心脏和血管系统。将雄性Sprague-Dawley大鼠暴露于轻度不可预测的环境应激源4周导致快感缺失，快感缺失在操作上定义为蔗糖摄入量减少，但对水摄入量无伴随影响。体液分析表明CMS暴露大鼠的肿瘤坏死因子-α（TNF-α）、白细胞介素-1 β（IL-1 β）、血浆肾素活性、醛固酮和皮质酮的血浆水平升高。下丘脑中的组织TNF-α和IL-1 β升高，垂体中的TNF-α升高。这些不道德的反应CMS，与快感缺乏作为抑郁症的指标在大鼠，可能与神经体液机制，可能有助于不良心脏事件。这些发现为更直接地研究与心脏病相关的抑郁症中中枢、内分泌和免疫系统之间的相互作用提供了基础。(c)2005年爱思唯尔公司All rights reserved.
A bidirectional relationship exists between depression and cardiovascular disease. Patients with major depression are more likely to develop cardiac events, and patients with myocardial infarction and heart failure are more likely to develop depression. A feature common to both clinical syndromes is activation of proinflammatory cytokines and stress hormones, including the hypothalamic-pituitary-adrenal axis and the renin-anaiotensin-aldosterone system. In the present study we examined the hypothesis that exposure to chronic mild stress (CMS), an experimental model of depression that induces anhedonia in rats, is sufficient to activate the production of proinflammatory cytokines and stress hormones that are detrimental to the heart and vascular system. Four weeks of exposure of male, Sprague-Dawley rats to mild unpredictable environmental stressors resulted in anhedonia which was operationally defined as a reduction in sucrose intake without a concomitant effect on water intake. Humoral assays indicated increased plasma levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), plasma renin activity, aldosterone, and corticosterone in the CMS exposed rats. Tissue TNF-alpha and IL-1 beta were increased in the hypothalamus, and TNF-alpha was increased in the pituitary gland. These Immoral responses to CMS, associated with anhedonia as an index of depression in the rat, are likely to be associated with neurohumoral mechanisms that may contribute to adverse cardiac events. The findings provide a basis for examining more directly the interactions among the central, endocrine, and immune systems in depression associated with heart disease. (c) 2005 Elsevier Inc. All rights reserved.