Epidemiology of COVID-19 Among Children in China
Epidemiology of COVID-19 Among Children in China
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DOI：
10.1542/peds.2020-0702
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发表时间：
2020-06-01
期刊：
影响因子：
8
通讯作者：
Tong, Shilu
中科院分区：
文献类型：
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作者：
Dong, Yuanyuan;Mo, Xi;Tong, Shilu
本研究采用回顾性分析方法对2135例小儿COVID-19患者的流行病学特征和传播模式进行了研究。目的：了解中国儿童2019年新型冠状病毒病（COVID-19）的流行病学特征和传播模式。方法：纳入2020年1月16日至2020年2月8日中国疾病预防控制中心报告的全国2135例小儿COVID-19病例系列。流行曲线由疾病发病和病例诊断的关键日期构成。通过对发病和诊断日期的数据拟合对数正态分布来构建发病-诊断曲线。结果：实验室确诊病例728例（34.1%），疑似病例1407例（65.9%）。所有患者的中位年龄为7岁（四分位数范围：2-13岁），男孩1208例（56.6%）。超过90%的患者为无症状、轻度或中度病例。从发病到诊断的中位时间为2天（范围：0-42天）。在流行病的早期，疾病迅速增加，然后逐渐稳定地减少。随着时间的推移，这种疾病迅速从湖北省传播到周边省份。湖北省的儿童感染人数比其他任何省份都多。结论：各年龄段儿童均易感染COVID-19，性别差异无统计学意义。虽然儿童新冠肺炎的临床表现普遍不如成人严重，但幼儿特别是婴幼儿易受感染。儿童新冠肺炎病例分布存在时空差异，主要集中在湖北省及周边地区。此外，本研究还提供了人际传播的有力证据。
This study examined the epidemiological characteristics and transmission patterns of 2135 pediatric patients with COVID-19 using a retrospective analytical approach. OBJECTIVE:To identify the epidemiological characteristics and transmission patterns of pediatric patients with the 2019 novel coronavirus disease (COVID-19) in China.METHODS:Nationwide case series of 2135 pediatric patients with COVID-19 reported to the Chinese Center for Disease Control and Prevention from January 16, 2020, to February 8, 2020, were included. The epidemic curves were constructed by key dates of disease onset and case diagnosis. Onset-to-diagnosis curves were constructed by fitting a log-normal distribution to data on both onset and diagnosis dates.RESULTS:There were 728 (34.1%) laboratory-confirmed cases and 1407 (65.9%) suspected cases. The median age of all patients was 7 years (interquartile range: 2-13 years), and 1208 case patients (56.6%) were boys. More than 90% of all patients had asymptomatic, mild, or moderate cases. The median time from illness onset to diagnoses was 2 days (range: 0-42 days). There was a rapid increase of disease at the early stage of the epidemic, and then there was a gradual and steady decrease. The disease rapidly spread from Hubei province to surrounding provinces over time. More children were infected in Hubei province than any other province.CONCLUSIONS:Children of all ages appeared susceptible to COVID-19, and there was no significant sex difference. Although clinical manifestations of children's COVID-19 cases were generally less severe than those of adult patients, young children, particularly infants, were vulnerable to infection. The distribution of children's COVID-19 cases varied with time and space, and most of the cases were concentrated in Hubei province and surrounding areas. Furthermore, this study provides strong evidence of human-to-human transmission.