Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma
Macula Vessel Density and Thickness in Early Primary Open-Angle Glaucoma
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DOI：
10.1016/j.ajo.2018.11.012
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发表时间：
2019-03-01
影响因子：
4.2
通讯作者：
Weinreb, Robert N.
中科院分区：
文献类型：
--
作者：
Hou, Huiyuan;Moghimi, Sasan;Weinreb, Robert N.
目的：表征和比较视野前和早期原发性开角型青光眼 (POAG) 眼的神经节细胞复合体 (GCC) 厚度和黄斑血管密度。设计：横断面研究。方法：参加青光眼诊断创新研究的 57 只健康眼、68 只视野前眼和 162 只早期 POAG 眼。同时评估基于光学相干断层扫描血管造影（OCT-A）的浅表黄斑血管密度和基于OCT的GCC厚度。比较了 GCC 厚度和黄斑血管密度相对于正常值的损失百分比。接受者操作特征曲线下面积用于描述诊断效用。结果：与健康眼睛相比，视野前和早期 POAG 眼睛的 GCC 厚度和血管密度均显着较低。与视野前 POAG 组相比，早期 POAG 组显示出更大的 GCC 厚度损失百分比（全图像 4.72% vs 9.86%；所有 P < .01），但血管密度百分比损失相似（全图像 4.97% vs 6.93%；所有 P > .05）。在预视野 POAG 中，GCC 厚度和血管密度百分比损失相似（所有 P > .1）。相反，在早期 POAG 中，GCC 厚度损失百分比大于血管密度损失百分比（均 P < .05）。结论：在视野前和早期 POAG 眼中，可以检测到 GCC 变薄和黄斑血管密度损失。在早期视野 POAG 中，GCC 损失大于黄斑血管密度损失。然而，OCT-A 和 OCT 测量显示检测早期青光眼的效率相似。 (C) 2018 Elsevier Inc. 保留所有权利。
PURPOSE: To characterize and compare the ganglion cell complex (GCC) thickness and macula vessel density in preperimetric and early primary open-angle glaucoma (POAG) eyes.DESIGN: Cross-sectional study.METHODS: Fifty-seven healthy, 68 preperimetric, and 162 early POAG eyes enrolled in the Diagnostic Innovations in Glaucoma Study. Optical coherence tomography angiography (OCT-A)-based superficial macula vessel density and OCT-based GCC thickness were evaluated simultaneously. Percent loss from normal of GCC thickness and macula vessel density was compared. Area under the receiver operating characteristic curve was used to describe the diagnostic utility.RESULTS: Both GCC thickness and vessel density were significantly lower in preperimetric and early POAG eyes compared to healthy eyes. Compared to the preperimetric POAG group, the early POAG group showed larger GCC thickness percent loss (whole image 4.72% vs 9.86%; all P < .01) but similar vessel density percent loss (whole image 4.97% vs 6.93%; all P > .05). In preperimetric POAG, GCC thickness and vessel density percent losses were similar (all P > .1). In contrast, in early POAG, GCC thickness percent loss was larger than that of vessel density (all P .05).CONCLUSIONS: Both GCC thinning and macula vessel density dropout were detectable in preperimetric and early POAG eyes. GCC loss was greater than macula vessel density loss in early perimetric POAG. However, OCT-A and OCT measurements showed similar efficiency to detect early glaucoma. (C) 2018 Elsevier Inc. All rights reserved.