Changes in indicators of inflammation after eccentric exercise of the elbow flexors
Changes in indicators of inflammation after eccentric exercise of the elbow flexors
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DOI：
10.1097/00005768-199608000-00003
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发表时间：
1996-08-01
期刊：
影响因子：
--
通讯作者：
Clarkson, PM
中科院分区：
文献类型：
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作者：
Nosaka, K;Clarkson, PM
这项研究检测了偏心运动诱导的肌肉损伤后肌肉肿胀和血液中炎症标记物的变化。未参加阻力训练的受试者(N=18)进行了24次肘屈肌的最大偏心动作。通过测量上臂围(CIR)、超声(USG)和磁共振成像(MRI)来评估肌肉肿胀。分析血浆白介素1α、白介素1β、白介素2、白介素6、肿瘤坏死因子α的浓度，以及C反应蛋白、皮质醇和锌的水平。已建立的肌肉损伤指标(最大等长力、活动范围、肌肉酸痛、血浆肌酸激酶、天冬氨酸氨基转移酶和乳酸脱氢酶活性)也被测量。所有指标，包括CIR和USG，除MRI外，在运动前、运动后即刻和运动后5d进行评估。分别于运动前、运动后1、3、6、10、23、31、58d进行MRI检查。所有肌肉损伤指标在运动后均有明显变化。运动后4-5d，CIR(>；20 mm)有较大幅度的增加，这与超声心动图一致，显示肌肉厚度增加。超声心动图的回声强度随屈肘肌群的增大而增大。运动后1d，MRI显示肱二头肌和肱二头肌横截面积增大，一直持续到23d。运动后3d或6d，MRI的放大程度和信号强度增加最为明显。然而，所有炎症标志物的血浆水平均未出现明显变化。结论：运动性肌肉损伤可引起肌肉肿胀，表现为肌肉水肿，但运动后的炎症反应与感染或组织损伤时的炎症反应不同。
This study examined muscle swelling and changes in inflammatory markers in the blood following eccentric exercise-induced muscle damage. Subjects (N = 18 who had not been involved in a resistance training program performed 24 maximal eccentric actions of the elbow flexors. Muscle swelling was assessed by measures of the upper arm circumference (CIR), ultrasonography (USG), and magnetic resonance imaging (MRI). Plasma concentrations of interleukin-1 alpha, interleukin-1 beta, interleukin-2, interleukin-6, tumor necrosis factor-alpha, and plasma levels of C-reactive protein, cortisol, and zinc were analyzed. Established indicators of muscle damage (maximal isometric force, range of motion, muscle soreness, and plasma creatine kinase, aspartate aminotransferase, and lactate dehydrogenase activities) were also measured. All measures, including CIR and USG, except for MRI, were assessed immediately before and after and for 5 d post-exercise. MRI was taken at pre- and 1, 3, 6, 10, 23, 31, and 58 d post-exercise. All muscle damage indicators changed significantly after exercise. A large increase in CIR (>20 mm) was found 4-5 d after exercise, and this coincided with USG, showing an increase in muscle thickness. The echointensity of USG increased with the enlargement of the elbow flexors. MRI displayed enlargement of the biceps brachii and brachialis cross-sectional area that started at 1 d, and lasted until 23 d, post-exercise. The most profound increase in the enlargement and signal intensity of the MRI was found 3 or 6 d after exercise. However, none of the plasma levels of inflammatory makers showed significant changes. It is concluded that exercise-induced muscle damage caused muscle swelling, which is indicative of muscle edema, but the inflammatory responses after exercise appear to be different from those accompanying infection or tissue injury.