Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children
Elevations in serum anti-flagellin and anti-LPS Igs are related to growth faltering in young Tanzanian children
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DOI：
10.3945/ajcn.116.131409
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发表时间：
2016-06-01
影响因子：
7.1
通讯作者：
Duggan, Christopher P.
中科院分区：
文献类型：
--
作者：
McDonald, Christine M.;Manji, Karim P.;Duggan, Christopher P.
Background: Antibodies to LPS and flagellin have been described as indirect measures of increased gastrointestinal permeability and may be markers of environmental enteric dysfunction (EED), which is a condition associated with poor child growth.Objective: We assessed whether LPS- and flagellin-specific immunoglobulin (Ig) concentrations were associated with poor growth in young Tanzanian children at risk of EED.Design: Blood samples were obtained from 590 children at 6 wk, 6 mo, and 12 mo of age. Serum LPS- and flagellin-specific Ig concentrations (IgA and IgG) were measured with the use of an ELISA. Growth was measured on a monthly basis for 18 mo.Results: Anti-LPS and anti-flagellin IgA and IgG concentrations increased over the first year of life and were higher than concentrations (measured at 9 mo of age) in healthy controls. Children with anti-flagellin IgA, anti-LPS IgA, anti-flagellin IgG, and anti-LPS IgG concentrations in the highest quartile at 6 wk of age were 2.02 (95% CI: 1.11, 3.67), 1.84 (95% CI: 1.03, 3.27), 1.94 (95% CI: 1.04, 3.62), and 2.31 (95% CI: 1.25, 4.27) times, respectively, more likely to become underweight (weight-for-age z score
