STRUCTURE AND PHYSIOLOGICAL-ACTIVITY OF MOTONEURONS OF NEMATODE ASCARIS
STRUCTURE AND PHYSIOLOGICAL-ACTIVITY OF MOTONEURONS OF NEMATODE ASCARIS
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DOI：
10.1073/pnas.75.7.3493
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发表时间：
1978-01-01
影响因子：
11.1
通讯作者：
KASS, IS
中科院分区：
文献类型：
--
作者：
STRETTON, AOW;FISHPOOL, RM;KASS, IS
线虫的神经系统含有约250个神经细胞，其中运动神经元由5个节段组成，每个节段包含11个细胞。在形态上，运动神经元分为7种不同类型。它们的几何形状很简单：一些是不分枝的，另一些有1个分支点，最复杂的有2个分支点。神经索中没有神经纤维；突触是通过轴突接触或在短棘上形成的。这些特点使得对该系统的解剖学和生理学的研究达到了在其他系统中很难做到的程度的完整性。研究了5个运动神经元的生理活性，其中3个是兴奋性的，2个是抑制性的。兴奋性运动神经元接受节间神经元的传入。抑制性运动神经元不接受中间神经元的输入；相反，它们接受兴奋性运动神经元的输入，该回路可能介导背侧和腹侧肌肉系统之间的相互抑制。
The nervous system of the nematode worm A. lumbricoides contained about 250 nerve cells; of these the motoneurons consist of 5 segmental sets, each containing 11 cells. Morphologically, the motoneurons was divided into 7 different types. Their geometry was simple: some were unbranched, others have 1 branch point, and the most complex had 2. There was no neuropil in the nerve cords; synapses were made by axo-axonal contact or onto short spines. These features enabled study of the anatomy and physiology of the system with a degree of completeness that would be difficult in other systems. The physiological activity of 5 of the motoneurons was investigated; 3 excitatory and 2 inhibitory. The excitatory motoneurons received input from intersegmental interneurons. The inhibitory motoneurons did not receive input from the interneurons; instead they received input from the excitatory motoneurons in a circuit that could mediate reciprocal inhibition between the dorsal and the ventral musculature.