The burden of rotavirus diarrhea in khanh hoa province, Vietnam - Baseline assessment for a rotavirus vaccine trial
The burden of rotavirus diarrhea in khanh hoa province, Vietnam - Baseline assessment for a rotavirus vaccine trial
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DOI：
10.1097/01.inf.0000195635.05186.52
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发表时间：
2006-01-01
影响因子：
3.6
通讯作者：
Glass, RI
中科院分区：
文献类型：
--
作者：
Anh, DD;Thiem, VD;Glass, RI
背景：在越南，轮状病毒被视为优先疾病，因为研究表明，> 50% 因腹泻住院治疗的儿童的病原体是轮状病毒。为了预测新疫苗的可用性，我们检查了越南庆和省芽庄的现场区域，将其作为未来进行轮状病毒疫苗现场试验的潜在地点。方法：对人口普查数据、先前霍乱疫苗试验的腹泻发病率以及从该省两家主要医院收集的计算机记录的住院率进行审查，以估计轮状病毒现场试验期间可能预期的轮状病毒相关腹泻负担结果：对于大约 5000 名儿童的出生队列，我们预计大约有 2500 次就诊和 650 - 850 例因腹泻治疗住院，其中大约 375 - 425 例归因于轮状病毒。对于越南出生的 1,639,000 名儿童来说，这些数字相当于每年因轮状病毒相关腹泻而进行的 820,000 次就诊、122,000 - 140,000 例住院治疗和 2900 - 5400 例死亡。结论：越南是新疫苗的早期采用者，儿童免疫接种的全国覆盖率很高（> 85%），并获得国际捐助者的支持用于引进新疫苗。我们发现越南农村地区轮状病毒的流行病学特征与发达国家轮状病毒的流行病学特征更相似，而不是印度或孟加拉国轮状病毒的流行病学特征。
Background: In Vietnam, rotavirus is seen as a priority disease because studies have demonstrated that > 50% of children hospitalized for treatment of diarrhea have rotavirus as the pathogen. To anticipate the availability of new vaccines, we have examined our field area in Nha Trang, Khanh Hoa Province, Vietnam, as a potential site to conduct a field trial of a future rotavirus vaccine.Methods: Data from a population census, incidence rates of diarrhea from a previous cholera vaccine trial and hospitalization rates from computerized records collected from the 2 main hospitals in the province were reviewed to estimate the burden of rotavirus-related diarrhea that might be expected during a field trial of a rotavirus vaccine.Results: For a birth cohort of similar to 5000 children, we would expect similar to 2500 clinic visits and 650 - 850 hospitalizations for treatment of diarrhea, of which similar to 375 - 425 would be attributable to rotavirus. For the Vietnamese birth cohort of 1,639,000 children, these numbers translate into similar to 820,000 clinic visits, 122,000 - 140,000 hospitalizations and 2900 - 5400 deaths annually attributable to rotavirus-related diarrhea.Conclusions: Vietnam is an early adaptor of new vaccines, has high national coverage rates (> 85%) for childhood immunization and receives international donor support for the introduction of new vaccines. We found the epidemiologic features of rotavirus in rural Vietnam to be more similar to those of rotavirus in a developed country than to those of rotavirus in India or Bangladesh.