Formal thought disorder in non-clinical individuals with auditory verbal hallucinations
Formal thought disorder in non-clinical individuals with auditory verbal hallucinations
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患有幻听的非临床个体的形式思维障碍
DOI：
10.1016/j.schres.2010.01.024
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发表时间：
2010
影响因子：
4.5
通讯作者：
M. Boks
中科院分区：
文献类型：
--
作者：
I. Sommer;Annelea M. C. Derwort;K. Daalman;A. D. Weijer;P. Liddle;M. Boks
听觉言语幻觉（AVH）和形式思维障碍（FTD）可能起源于语言系统中相同的畸变。一个共享的神经生物学基础的假设将加强FTD在个人谁经常经历AVH的存在，但不符合DSM-IV标准的精神病disorder. METHODS在这项研究中，FTD进行了定量在40个非临床受试者与AVH，在50名健康受试者没有AVH和40名精神分裂症患者与AVH。由一名对是否存在AVH和诊断不知情的评估者使用思维和语言指数分析记录的语音样本。在非临床AVH受试者和无AVH的健康对照者中几乎不存在阴性FTD。然而，发生AVH的两组中FTD阳性率均显著高于未发生AVH的对照组。阳性FTD的严重程度在非临床AVH受试者和伴有AVH.CONCLUSIONNegative FTD（失语症）的精神分裂症患者之间没有显著差异。然而，伴有AVH的精神分裂症患者中FTD（言语紊乱）阳性率与伴有AVH的非临床受试者中FTD阳性率相同，这一事实表明这两种症状往往同时发生，这可能提示存在共同的神经生物学底物。
BACKGROUNDAuditory verbal hallucinations (AVH) and formal thought disorder (FTD) may originate from the same aberration in the language system. The hypothesis of a shared neurobiological basis would be strengthened by the presence of FTD in individuals who frequently experience AVH, but do not meet DSM-IV criteria for a psychotic disorder.METHODSIn this study, FTD was quantified in 40 non-clinical subjects with AVH, in 50 healthy subjects without AVH and in 40 schizophrenia patients with AVH. Recorded speech samples were analysed by one rater who was blind to the presence/absence of AVH and to diagnosis, using the Thought and Language Index.RESULTSNegative FTD was barely present in non-clinical subjects with AVH and in healthy controls without AVH. Positive FTD, however, was significantly higher in both groups experiencing AVH than in controls without AVH. Severity of positive FTD did not differ significantly between non-clinical subjects with AVH and schizophrenia patients with AVH.CONCLUSIONNegative FTD (alogia) appears not to be associated with AVH. However, the fact that positive FTD (disorganised speech) in schizophrenia patients with AVH is equally high in non-clinical subjects with AVH indicates that these two symptoms tend to co-occur, which may be suggestive of a shared neurobiological substrate.
影响因子：
3.7
作者：
Hoffman, Ralph E.;Hampson, Michelle;Krystal, John H.
通讯作者：
Krystal, John H.
影响因子：
--
作者：
N. Andreasen;M. Flaum;Stephan Arndt
通讯作者：
N. Andreasen;M. Flaum;Stephan Arndt