High bone mass in the STR/ort mouse results from increased bone formation and impaired bone resorption and is associated with extramedullary hematopoiesis
High bone mass in the STR/ort mouse results from increased bone formation and impaired bone resorption and is associated with extramedullary hematopoiesis
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DOI：
10.1007/s00774-012-0394-9
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发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Mueller-Hilke, Brigitte
中科院分区：
文献类型：
--
作者：
Pasold, Juliane;Engelmann, Robby;Mueller-Hilke, Brigitte
我们在此描述了STR/ort小鼠中新的高骨量表型，其导致皮质骨和松质骨骨量增加，并与成骨细胞活性升高和破骨细胞功能受损相关。STR/ort和C57 BL/6小鼠的比较揭示了椎骨和股骨干骺端的骨小梁体积的增加。在雌性中，早在2个月大时这种差异就很显著，在9个月大时，雌性在所有测量参数上都远远超过其年龄匹配的雄性。股骨干皮质骨质量增加是由于骨内膜表面贴壁所致，早在1月龄时，两种性别的股骨干皮质骨质量增加均显著，并导致骨髓压缩和髓外造血。成骨细胞和破骨细胞两者的活性改变有助于高骨量，并且这种表型共同支持多因素发病机制。此外，雄性STR/ort小鼠中骨关节炎的自发发展提示骨小梁质量与关节软骨退行性变化的发展之间存在密切相关性。
We here describe the novel high bone mass phenotype in STR/ort mice that leads to increased bone masses of cortical and trabecular bone and is associated with elevated osteoblast activity and impaired osteoclast function alike. Comparison of STR/ort and C57BL/6 mice reveals an increase in trabecular bone volumes of the vertebrae and at femoral metaphysis. In the females, this difference is significant as early as 2 months of age and at 9 months the females by far exceed their age matched males in all parameters measured. The increase in cortical bone mass at femoral diaphysis results from an apposition to the endosteal surface, it is significant for both sexes as early as 1 month of age and leads to bone marrow compression and extramedullary hematopoiesis. Altered activities of both, the osteoblast and the osteoclast contribute to the high bone mass and collectively this phenotype supports a multifactorial pathogenesis. Moreover, the spontaneous development of osteoarthritis in male STR/ort mice is suggestive of a tight correlation between trabecular bone mass and the development of degenerative changes of the articular cartilage.