Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants.
Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants.
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前列腺素、生长因子和合成化学引诱剂的新血管生成能力。
DOI：
10.1016/0002-9394(78)90289-1
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发表时间：
1978
影响因子：
4.2
通讯作者：
D. Benezra
中科院分区：
文献类型：
--
作者：
D. Benezra
测试前列腺素E1、E2、D2、A1、F1 α和F2 α以及合成的化学引诱剂和生长因子诱导兔角膜中新血管增殖的能力。在所有病例中，PGE1显示出最强的新生血管生成活性，吸引新血管。PGE_2的引诱作用弱于PGE_1。PGF2 α诱导的反应不太一致。所有隔离PGD2或PGA 1的植入物均为阴性。植入物隔离1微克的成纤维细胞生长因子或表皮生长因子β刺激角膜细胞和上皮细胞在体内的增殖。然而，这些都没有表现出任何血管生成活性。仅在每个植入物隔离10微克生长因子的植入物中观察到小但显着的新血管形成。虽然在体外有活性，但神经生长因子和甲酰化合成肽在体内没有刺激性。
Prostaglandins E1, E2, D2, A1, F1alpha, and F2alpha as well as synthetic chemoattractants and growth factors were tested for their ability to induce the proliferation of new blood vessels in the rabbit cornea. PGE1 showed the strongest neovasculogenic activity attracting new blood vessels in all of the cases. PGE2 was a weaker attractant than PGE1. PGF2alpha induced a less consistent reaction. All implants sequestering PGD2 or PGA1 were negative. Implants sequestering 1 microgram of fibroblast growth factor or epidermal growth factor variably stimulated the proliferation of keratocytes and epithelial cells in vivo. However, none of these demonstrated any vasculogenic activity. A small, but significant neovascularization was observed only in implants sequestering 10 microgram of growth factor per implant. Although active in vitro, nerve growth factor and formylated synthetic peptides were not stimulatory in vivo.