Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities.
Pediatric Brain Tumors: Current Knowledge and Therapeutic Opportunities.
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DOI：
10.1097/mph.0000000000000551
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Israel MA
中科院分区：
文献类型：
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作者：
Glod J;Rahme GJ;Kaur H;H Raabe E;Hwang EI;Israel MA
儿科肿瘤学的许多领域都取得了很大的进展。然而，中枢神经系统（CNS）的肿瘤仍然是一个重大的挑战。最近的数据爆炸带来了更好地了解这些疾病的分子基础的机会，并且已经为追求合理选择靶向相关分子途径的治疗方法提供了基础。儿科脑肿瘤的分子生物学正在从单一的基础科学发现转向一个平台，在这个平台上，见解正在转化为治疗方法。
Great progress has been made in many areas of pediatric oncology. However, tumors of the central nervous system (CNS) remain a significant challenge. A recent explosion of data has led to an opportunity to understand better the molecular basis of these diseases and is already providing a foundation for the pursuit of rationally chosen therapeutics targeting relevant molecular pathways. The molecular biology of pediatric brain tumors is shifting from a singular focus on basic scientific discovery to a platform upon which insights are being translated into therapies.