Neuroendocrine aging in men - Andropause and somatopause
Neuroendocrine aging in men - Andropause and somatopause
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DOI：
10.1016/s0889-8529(05)70206-1
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发表时间：
2001-09-01
影响因子：
4.5
通讯作者：
Merriam, GR
中科院分区：
文献类型：
--
作者：
Anawalt, BD;Merriam, GR
睾酮和生长激素（GH）在青春期显著上升，并有助于身体成分和肌肉力量的成熟变化。这两种热带激素在成年期达到平台，然后，由于中枢和睾丸变化的结合，随着年龄的增长而逐渐下降，伴随着肌肉和力量的损失以及类似于部分性腺功能减退或GH缺乏症的体脂增加。这些相似之处导致了猜测，然后进行了临床研究，以测试补充睾酮，GH或两者是否可以逆转这些与年龄相关的变化，增强力量和身体功能，并延长独立生活的能力。到目前为止进行的研究鼓励这种可能性，特别是对于睾酮水平非常低的男性的雄激素，但发表的报告太有限，不能推荐大多数健康老年男性一般临床使用雄激素，GH或GH促分泌素。
Testosterone and growth hormone (GH) rise markedly at puberty and contribute to maturational changes in body composition and muscle strength. Both tropic hormones plateau in adult life, and then, because of a combination of central and testicular changes, decline progressively with aging, accompanied by loss of muscle and strength and an increase in body fat that resembles partial hypogonadism or GH deficiency. These parallels have led to speculation and then to clinical studies to test whether supplementing testosterone, GH, or the two together could reverse these age-related changes, boost strength and physical function, and prolong the capacity for independent living. Studies conducted so far encourage this possibility, especially for androgens in men with very low testosterone levels, but published reports are too limited to recommend the general clinical use of androgens, GH, or GH secretagogues in most healthy older men.