Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
复制标题
细胞周期基因和卵巢癌易感性：tagSNP 分析。
DOI：
10.1038/sj.bjc.6605284
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发表时间：
2009-10-20
影响因子：
8.8
通讯作者：
Goode, E. L.
中科院分区：
文献类型：
--
作者：
Cunningham, J. M.;Vierkant, R. A.;Sellers, T. A.;Phelan, C.;Rider, D. N.;Liebow, M.;Schildkraut, J.;Berchuck, A.;Couch, F. J.;Wang, X.;Fridley, B. L.;Gentry-Maharaj, A.;Menon, U.;Hogdall, E.;Kjaer, S.;Whittemore, A.;DiCioccio, R.;Song, H.;Gayther, S. A.;Ramus, S. J.;Pharaoh, P. D. P.;Goode, E. L.
细胞周期失调是许多癌症的标志，包括卵巢癌，卵巢癌是全球妇科癌症死亡率的主要原因。我们在一项两阶段研究中检测了39个细胞周期调控基因的单核苷酸多态性（SNPs）（n=288），包括细胞周期蛋白、细胞周期蛋白依赖性激酶（CDK）和CDK抑制剂。使用Illumina测定法对白色非西班牙裔病例（n=829）和无卵巢癌对照（n=941）进行基因分型。在至少一种遗传模型中，9个基因（ABL 1、CCNB 2、CDKN 1A、CCND 3、E2 F2、CDK 2、E2 F3、CDC 2和CDK 7）的11种变异与卵巢癌风险相关。然后在另外四项研究中评估了7个SNP，其中包括1689例病例和3398例对照。在原始人群中发现的卵巢癌风险与ABL 1 rs 2855192之间的相关性[比值比，ORBB vs AA 2.81（1.29-6.09），P=0.01]也在重复人群中观察到，在联合分析中该相关性仍然提示[ORBB vs AA 1.59（1.08-2.34），P=0.02]。在复制人群中没有其他SNP相关性。ABL 1参与多种过程，包括细胞分裂、细胞粘附和细胞应激反应。这些结果表明，该基因在其他卵巢癌人群中的遗传变异功能的表征是必要的。
Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide. We examined single nucleotide polymorphisms (SNPs) (n=288) from 39 cell cycle regulation genes, including cyclins, cyclin-dependent kinases (CDKs) and CDK inhibitors, in a two-stage study. White, non-Hispanic cases (n=829) and ovarian cancer-free controls (n=941) were genotyped using an Illumina assay. Eleven variants in nine genes (ABL1, CCNB2, CDKN1A, CCND3, E2F2, CDK2, E2F3, CDC2, and CDK7) were associated with risk of ovarian cancer in at least one genetic model. Seven SNPs were then assessed in four additional studies with 1689 cases and 3398 controls. Association between risk of ovarian cancer and ABL1 rs2855192 found in the original population [odds ratio, ORBB vs AA 2.81 (1.29–6.09), P=0.01] was also observed in a replication population, and the association remained suggestive in the combined analysis [ORBB vs AA 1.59 (1.08–2.34), P=0.02]. No other SNP associations remained suggestive in the replication populations. ABL1 has been implicated in multiple processes including cell division, cell adhesion and cellular stress response. These results suggest that characterization of the function of genetic variation in this gene in other ovarian cancer populations is warranted.
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DOI：
10.1158/1055-9965.epi-07-2849
发表时间：
2008-07
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Cunningham JM;Sellers TA;Schildkraut JM;Fredericksen ZS;Vierkant RA;Kelemen LE;Gadre M;Phelan CM;Huang Y;Meyer JG;Pankratz VS;Goode EL
通讯作者：
Goode EL
影响因子：
4.7
作者：
Lancaster, Johnathan M.;Powell, C. Bethan;Herzog, Thomas J.
通讯作者：
Herzog, Thomas J.
影响因子：
3.3
作者：
Hashiguchi, Y;Tsuda, H;Kawamura, N
通讯作者：
Kawamura, N
DOI：
10.1016/j.ejca.2008.07.010
发表时间：
2008-10
期刊：
European journal of cancer (Oxford, England : 1990)
影响因子：
--
作者：
Mann A;Hogdall E;Ramus SJ;DiCioccio RA;Hogdall C;Quaye L;McGuire V;Whittemore AS;Shah M;Greenberg D;Easton DF;Ponder BA;Kjaer SK;Gayther SA;Thompson DJ;Pharoah PD;Song H
通讯作者：
Song H
影响因子：
3.8
作者：
Beesley, Jonathan;Jordan, Susan J.;Chenevix-Trench, Georgia
通讯作者：
Chenevix-Trench, Georgia