Three-dimensional analysis of the palatal morphology in growing patients with Apert syndrome and Crouzon syndrome
Three-dimensional analysis of the palatal morphology in growing patients with Apert syndrome and Crouzon syndrome
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阿佩尔综合征和克鲁宗综合征生长发育患者腭部形态的三维分析
DOI：
10.1111/cga.12470
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
K.
中科院分区：
文献类型：
--
作者：
Ogura;K. Kobayashi;Y. Hikita;R. Tsuji;M. Moriyama;K.
Apert综合征或Crouzon综合征患者在口腔颌面部生长和发育方面存在严重缺陷。在这项研究中，我们对Apert综合征和Crouzon综合征患者的腭部形态进行了定量三维（3D）分析。研究了4例Apert综合征患者（平均年龄，11.0 ± 0.8岁）和5例Crouzon综合征患者（平均年龄，10.1 ± 1.6岁）。使用3D成像扫描和分析参与者的上颌牙模。测量腭宽、深度、横截面积和腭角（分别为PW、PD、PCA和PA），并根据性别和年龄匹配的日本标准值计算标准评分;还测量实际腭表面积（PSA）和腭体积（PV）。我们的研究结果表明，Apert综合征和Crouzon综合征患者的PW非常窄（标准评分分别为-3.79和-0.47）。3D分析显示，Apert综合征患者的PD（标准评分：-1.35）显著低于Crouzon综合征患者（标准评分：2.47），导致PCA（标准评分：-5.13）、PSA（5.49 cm 2）和PV（1.11 cm 3）小于Crouzon综合征患者，PA（标准评分：-0.12）大于Crouzon综合征患者。这可能是由于前者的腭部较窄且较浅，这是由腭部粘膜的主要肿胀引起的。这些发现提高了我们对Apert综合征和Crouzon综合征患者腭部形态差异的理解。
Patients with Apert syndrome or Crouzon syndrome present with severe defects in oral‐maxillofacial growth and development. In this study, we conducted a quantitative three‐dimensional (3D) analysis of the palatal morphology of patients with Apert syndrome and Crouzon syndrome. Four patients with Apert syndrome (average age, 11.0 ± 0.8 years) and five with Crouzon syndrome (average age, 10.1 ± 1.6 years) were investigated. The participants' maxillary dental casts were scanned and analyzed using 3D imaging. Palatal width, depth, cross‐sectional area, and palatal angle (PW, PD, PCA, and PA, respectively) were measured, and standard scores were calculated based on sex‐ and age‐matched Japanese standard values; the actual palatal surface areas (PSA) and palatal volumes (PV) were also measured. Our results show that patients with Apert syndrome and Crouzon syndrome had a very narrow PW (standard score: −3.79 and − 0.47, respectively). 3D analysis revealed that patients with Apert syndrome had a significantly shallower PD (standard score: −1.35) than those with Crouzon syndrome (standard score: 2.47), resulting in a smaller PCA (standard score: −5.13), PSA (5.49 cm2), and PV (1.11 cm3) and larger PA (standard score: −0.12) than those in patients with Crouzon syndrome. This might be due to the former having a narrower and shallower palate caused by the predominant swelling of the palatal mucosa. These findings improve our understanding of the differences in palatal morphology between Apert syndrome and Crouzon syndrome patients.