[Icariin and its pharmaceutical efficacy: research progress of molecular mechanism].
[Icariin and its pharmaceutical efficacy: research progress of molecular mechanism].
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DOI：
10.3736/jcim20111104
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发表时间：
2011-11-01
期刊：
影响因子：
--
通讯作者：
Shen, Zi-yin
中科院分区：
文献类型：
--
作者：
Chen, Yang;Huang, Jian-hua;Shen, Zi-yin
淫羊藿苷是淫羊藿属植物的重要活性成分之一，在中药中应用最为广泛。科学研究发现淫羊藿苷具有广泛的治疗作用，如保护神经元免受损伤，促进神经元突触生长，改善性功能障碍和骨形态发生，以及抗炎、抗肿瘤和抗抑郁等功能。考虑到分子机制是淫羊藿苷药效的根本依据，本文回顾性检索了1995年1月1日至2011年1月5日PubMed数据库收录的122篇题名为“淫羊藿苷”的科学论文。研究发现淫羊藿苷在p38丝裂原活化蛋白激酶和磷脂酰肌醇3-激酶/Akt信号通路的干预、磷酸二酯酶5的抑制和核受体的调控中被密切关注。并对淫羊藿苷分子机理的研究方向进行了展望。
Icariin is one of the key active components of Epimedium species, which is most widely applied to supplement the kidney in traditional Chinese medicine. Scientific research has found that icariin possesses extensive therapeutic effects such as protecting neurons from injury, promoting growth of neuronal synapse, improving sexual dysfunction and bone morphogenesis, as well as anti-inflammation, anti-tumor and anti-depression functions. Considering that molecular mechanism is the fundamental basis for pharmaceutical efficacy of icariin, in this article, the authors retrospectively retrieved 122 scientific papers recorded in the PubMed database with "icariin" in the title from January 1, 1995 to January 5, 2011. It was found that icariin has been closely highlighted in the intervention of p38 mitogen-activated protein kinases and phosphatidylinositol 3-kinase/Akt signal pathways, inhibition of phosphodiesterase 5, and regulation of nuclear receptors. Besides, the authors also discussed the main orientation for molecular mechanism of icariin in future research.