Ca2+-ATPase deficiency in a patient with an exertional muscle pain syndrome.
Ca2+-ATPase deficiency in a patient with an exertional muscle pain syndrome.
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劳力性肌肉疼痛综合征患者存在 Ca2-ATP 酶缺乏症。
DOI：
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发表时间：
1988
影响因子：
11
通讯作者：
G. Radda
中科院分区：
文献类型：
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作者：
D. Taylor;M. Brosnan;D. Arnold;P. Bore;P. Styles;J. Walton;G. Radda
对一名患有维拉帕米反应性慢性进行性运动后肌肉疼痛的患者的骨骼肌进行了体内31 P磁共振波谱研究。一个妹妹也有类似的抱怨。结果表明：（1）运动期间肌肉高能磷酸盐含量比正常情况下降得更快，表明ATP的利用率增加或产生量减少;（2）运动期间酸化比正常情况更快，表明糖酵解率增加;（3）在一些研究中，在运动后的第一分钟内继续显着酸化，表明糖酵解在恢复期内保持活性;（4）具有与氧化磷酸化的正常速率一致的磷酸肌酸和ADP恢复速率。根据这些结果，提出患者患有肌肉中Ca 2+处理缺陷。随后，直接测量肌浆网部分从肌肉活检样品中的Ca 2 +-ATP酶活性表明，这种酶的活性降低了约90%。
31P Magnetic resonance spectroscopy studies were carried out in vivo on skeletal muscle of a patient with verapamil-responsive, chronic, progressive post-exertional muscle pain. A sister suffered from a similar complaint. The results showed that the muscle: (1) decreased its high energy phosphate content more rapidly than normal during exercise, indicating either increased utilisation or decreased production of ATP; (2) acidified more rapidly than normal during exercise suggesting an increased glycolytic rate; (3) continued in some studies to acidify markedly during the first minute after exercise, indicating that glycolysis remained active into the recovery period; (4) had phosphocreatine and ADP recovery rates consistent with normal rates of oxidative phosphorylation. On the basis of these results, it was proposed that the patient suffers from a defect in Ca2+ handling in the muscle. Subsequently, direct measurement of Ca2+-ATPase activity in the sarcoplasmic reticulum fraction from a muscle biopsy sample showed that the activity of this enzyme was reduced by about 90%.
通过 31P-NMR 研究 McArdle 病的肌肉疲劳：葡萄糖输注的影响。
DOI：
10.1152/jappl.1985.59.6.1991
发表时间：
1985
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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作者：
Lewis,SF;Haller,RG;Cook,JD;Nunnally,RL
通讯作者：
Nunnally,RL