Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives
Antibacterial and Antiviral Activities of 1,3,4-Oxadiazole Thioether 4H-Chromen-4-one Derivatives
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1,3,4-恶二唑硫醚4H-Chromen-4-one衍生物的抗菌和抗病毒活性
DOI：
10.1021/acs.jafc.1c03755
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发表时间：
2021-09-13
影响因子：
6.1
通讯作者：
Xue, Wei
中科院分区：
文献类型：
--
作者：
Peng, Feng;Liu, Tingting;Xue, Wei
提出了各种1,3,4-恶二唑硫醚4h -铬-4- 1衍生物。标题化合物对Xac、Psa和Xoo具有显著的抑制作用。EC50数据显示，A8 （19.7 μ g/mL）对Xoo的抑菌活性优于杨梅素、BT和TC。同时，通过扫描电镜对A8的作用机理进行了验证。抗烟草花叶病毒实验结果表明，A9与宁南霉素相比具有较好的体内抗病毒效果。从MST数据可以看出，A9 （0.003 +/- 0.001 mu mol/L）的结合能力较强，远优于宁南霉素（2.726 +/- 1.301 mu mol/L）。本研究表明，1,3,4-恶二唑硫醚4h -铬-4- 1衍生物可能成为具有巨大潜力的农用药物。
Various 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives were conceived. The title compounds demonstrated striking inhibitory effects against Xac, Psa, and Xoo. EC50 data exhibited that A8 (19.7 mu g/mL) had better antibacterial activity against Xoo than myricetin, BT, and TC. Simultaneously, the mechanism of action of A8 had been verified by SEM. The results of anti-tobacco mosaic virus indicated that A9 had the best in vivo antiviral effect compared with ningnanmycin. From the data of MST, it could be seen that A9 (0.003 +/- 0.001 mu mol/L) exhibited a strong binding capacity, which was far superior to ningnanmycin (2.726 +/- 1.301 mu mol/L). This study shows that the 1,3,4-oxadiazole thioether 4H-chromen-4-one derivatives may become agricultural drugs with great potential.