Laser in situ keratomileusis-induced neurotrophic epitheliopathy
Laser in situ keratomileusis-induced neurotrophic epitheliopathy
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DOI：
10.1016/s0002-9394(01)00995-3
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发表时间：
2001-09-01
影响因子：
4.2
通讯作者：
Ambrosio, R
中科院分区：
文献类型：
--
作者：
Wilson, SE;Ambrosio, R
目的：报道两例激光原位角膜磨镶术引起的神经营养性上皮病，伴有点状上皮病变和角膜瓣孟加拉红染色。方法：干预病例报告。结果：术前无干眼症状或体征的 42 岁女性和 37 岁男性出现干眼症状，双侧点状上皮糜烂，角膜瓣孟加拉红染色。激光原位角膜磨镶术后的角膜瓣。在皮瓣表面异常发生和消退之间的任何时间点，没有麻醉的 Schirmer 试验中，两名患者的湿润程度均未低于 12 毫米。激光原位角膜磨镶术后约6个月，角膜瓣表面异常得到解决。结论：激光原位角膜磨镶术引起的神经营养性上皮病可能是由于切断的角膜神经干导致营养影响丧失所致。这种情况通常在激光原位角膜磨镶术或激光原位角膜磨镶术再治疗后约 6 个月得到缓解。 （美国眼科杂志 2001 年；132：405-406。(C) 2001 年，Elsevier Science Inc. 保留所有权利。）。
PURPOSE: To report two cases of laser in situ keratomileusis-induced neurotrophic epitheliopathy with punctate epitheliopathy and rose bengal staining of the corneal flap.METHODS: Interventional case reports.RESULTS: A 42-year,old woman and a 37-year old man with no preoperative symptoms or signs of dry eye developed dry eye symptoms and bilateral punctate epithelial erosions as well as rose bengal staining of the corneal flaps after laser in situ keratomileusis. Neither patient had less than 12 mm of wetting with the Schirmer test without anesthesia at any time point between development and resolution of the flap surface abnormalities. The flap surface abnormalities resolved approximately 6 months after laser in situ keratomileusis.CONCLUSIONS: Laser in situ keratomileusis,induced neurotrophic epitheliopathy may be attributable to loss of trophic influence from severed corneal nerve trunks. The condition typically resolves approximately 6 months after laser in situ keratomileusis or laser in situ keratomileusis retreatment. (Am J Ophthalmol 2001;132:405-406. (C) 2001 by Elsevier Science Inc. All rights reserved.).