Tumor induction with hexanal methylformylhydrazone of Gyromitra esculenta.
Tumor induction with hexanal methylformylhydrazone of Gyromitra esculenta.
复制标题
用鹿花己醛甲基甲酰腙诱导肿瘤。
DOI：
10.1007/bf00436794
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发表时间：
1991
期刊：
影响因子：
5.5
通讯作者：
Gannett,P
中科院分区：
文献类型：
--
作者：
Toth,B;Taylor,J;Gannett,P
以50或100 μ g/g体重，每周52次胃内滴注己醛甲基甲酰腙（HMFH）给瑞士小鼠。这种治疗诱发了肺、肝和包皮腺的肿瘤。接受较低剂量组的雌性动物肿瘤发生率为74、4和0%，雄性动物为78、8和6%。在较高剂量组中，雌性动物的发生率分别为90%、28%和0%，雄性动物为70%、6%和86%。在未给药动物中，雌性动物的相应肿瘤发生率为26%、0%和0%，雄性动物为26%、0%和0%。组织病理学检查发现肺腺瘤和腺癌、良性肝癌和肝细胞癌、鳞状细胞乳头状瘤和包皮腺癌和腺瘤。HMFH是在假羊肚菌中发现的第六种致癌成分，Gyromitra esculenta。由于这种真菌被认为是可食用的，因此对健康的危害不容忽视。
Hexanal methylformylhydrazone (HMFH) was administered to Swiss mice by intragastric instillations at weekly intervals of 52 times at 50 or 100 μ/g body weight. The treatment induced tumors of the lungs, liver and preputial glands. The tumor incidences in the group that received the lower dose were 74, 4 and 0% in females and 78, 8 and 6% in the males. In the group with the higher dose, the incidences were 90, 28 and 0% in females and 70, 6 and 86% in males. The corresponding tumor incidences in the untreated animals were 26, 0 and 0% in females and 26, 0 and 0% in males. The histopathological examination revealed adenomas and adenocarcinomas of lungs, benign hepatomas and liver cell carcinomas and squamous cell papillomas and carcinomas and adenomas of preputial glands. HMFH is the sixth carcinogenic ingredient found in one of the false morel mushrooms, Gyromitra esculenta. Because this fungus is considered edible, the health hazard implications cannot be discounted.