Spirochetal Lipoproteins and Immune Evasion.
Spirochetal Lipoproteins and Immune Evasion.
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DOI：
10.3389/fimmu.2017.00364
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发表时间：
2017
影响因子：
7.3
通讯作者：
Kelesidis T
中科院分区：
文献类型：
--
作者：
Christodoulides A;Boyadjian A;Kelesidis T
螺旋体是公共卫生的主要威胁。然而，螺旋体疾病的确切发病机制仍不清楚。螺旋体表达的脂蛋白通常决定宿主和螺旋体之间的相互作用。脂蛋白是促炎性的，调节免疫反应，并使螺旋体能够逃避免疫系统。本文就螺旋体脂蛋白对免疫逃避的调节作用作一综述。了解脂蛋白诱导的免疫调节将有助于阐明先天发病过程和随后的适应性机制可能与螺旋体病疫苗的开发和治疗。
Spirochetes are a major threat to public health. However, the exact pathogenesis of spirochetal diseases remains unclear. Spirochetes express lipoproteins that often determine the cross talk between the host and spirochetes. Lipoproteins are pro-inflammatory, modulatory of immune responses, and enable the spirochetes to evade the immune system. In this article, we review the modulatory effects of spirochetal lipoproteins related to immune evasion. Understanding lipoprotein-induced immunomodulation will aid in elucidating innate pathogenesis processes and subsequent adaptive mechanisms potentially relevant to spirochetal disease vaccine development and treatment.