Epigenetic control of hematopoietic stem cell aging - The case of Ezh2
Epigenetic control of hematopoietic stem cell aging - The case of Ezh2
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DOI：
10.1196/annals.1392.008
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Gerrits, Alice
中科院分区：
文献类型：
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作者：
de Haan, Gerald;Gerrits, Alice
造血干细胞具有强大但不是无限的自我更新潜能。限制自我更新的机制可能在衰老过程中发挥作用。最近的数据表明，Polycomb组蛋白修饰的调控可能与平衡自我更新和衰老有关。我们提供的证据表明，这些Polycomb组基因之一Ezh2参与造血干细胞系统的衰老。
Hematopoietic stem cells have potent, but not unlimited, selfrenewal potential. The mechanisms that restrict selfrenewal are likely to play a role during aging. Recent data suggest that the regulation of histone modifications by Polycomb group genes may be of crucial relevance to balance selfrenewal and aging. We provide evidence for the involvement of one of these Polycomb group genes, Ezh2, in aging of the hematopoietic stem cell system.