Influence of mindfulness-based stress reduction (MBSR) on telomerase activity in women with breast cancer (BC).
Influence of mindfulness-based stress reduction (MBSR) on telomerase activity in women with breast cancer (BC).
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DOI：
10.1177/1099800413519495
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发表时间：
2014-10
影响因子：
2.5
通讯作者：
Park JY
中科院分区：
文献类型：
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作者：
Lengacher CA;Reich RR;Kip KE;Barta M;Ramesar S;Paterson CL;Moscoso MS;Carranza I;Budhrani PH;Kim SJ;Park HY;Jacobsen PB;Schell MJ;Jim HS;Post-White J;Farias JR;Park JY
正念减压（MBSR）可以减少乳腺癌（BC）幸存者的抑郁、焦虑和对复发的恐惧症状。然而，MBSR（BC）对端粒长度（TL）和端粒酶活性（TA）的影响，细胞衰老，心理压力和疾病风险的已知标志物，尚不清楚。这项随机、等待、对照的研究，嵌套在一个更大的试验中，调查了MBSR（BC）对TL和TA的影响。入选前至少2周完成放疗和/或化疗辅助治疗，且在完成乳房肿瘤切除术和/或乳房切除术治疗后2年内完成放疗和/或化疗的0-III期乳腺癌患者（142例）被随机分配接受为期6周的MBSR治疗或常规治疗。在基线、6周和完成MBSR（BC）项目后12周，获得TA和TL的评估沿着心理测量。142名参与者的平均年龄为55.3岁; 72%是非西班牙裔白色人; 78%患有I期或II期癌症; 36%接受化疗和放疗。在校正基线TA和心理状态的分析中，MBSR（BC）组的TA在12周内稳定增加（约17%），而对照组基本上没有增加（约3%，p <0.01）。相比之下，TL未观察到组间差异（p = 0.92）。这些结果提供了初步的证据，MBSR（BC）增加TA从BC患者外周血单核细胞和理解MBSR（BC）如何在细胞水平上延长细胞寿命的影响。
Mindfulness-based stress reduction (MBSR) reduces symptoms of depression, anxiety, and fear of recurrence among breast cancer (BC) survivors. However, the effects of MBSR (BC) on telomere length (TL) and telomerase activity (TA), known markers of cellular aging, psychological stress, and disease risk, are not known. This randomized, wait-listed, controlled study, nested within a larger trial, investigated the effects of MBSR (BC) on TL and TA. BC patients (142) with Stages 0–III cancer who had completed adjuvant treatment with radiation and/or chemotherapy at least 2 weeks prior to enrollment and within 2 years of completion of treatment with lumpectomy and/or mastectomy were randomly assigned to either a 6-week MBSR for BC program or a usual care. Assessments of TA and TL were obtained along with psychological measurements at baseline, 6 weeks, and 12 weeks after completing the MBSR(BC) program. The mean age of 142 participants was 55.3 years; 72% were non-Hispanic White; 78% had Stage I or II cancer; and 36% received both chemotherapy and radiation. In analyses adjusted for baseline TA and psychological status, TA increased steadily over 12 weeks in the MBSR(BC) group (approximately 17%) compared to essentially no increase in the control group (approximately 3%, p < .01). In contrast, no between-group difference was observed for TL (p = .92). These results provide preliminary evidence that MBSR(BC) increases TA in peripheral blood mononuclear cells from BC patients and have implications for understanding how MBSR(BC) may extend cell longevity at the cellular level.