Impaired bone strength estimates at the distal tibia and its determinants in adolescents with anorexia nervosa.
Impaired bone strength estimates at the distal tibia and its determinants in adolescents with anorexia nervosa.
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DOI：
10.1016/j.bone.2017.07.009
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发表时间：
2018-01
期刊：
影响因子：
4.1
通讯作者：
Klibanski A
中科院分区：
文献类型：
--
作者：
Singhal V;Tulsiani S;Campoverde KJ;Mitchell DM;Slattery M;Schorr M;Miller KK;Bredella MA;Misra M;Klibanski A
骨骼微结构改变和较高的骨髓脂肪组织(MAT)可能会降低骨强度。高分辨率pQCT(HRpQCT)可以评估体积骨密度(VBMD)，以及骨的大小和微结构参数，而1H-磁共振波谱(1H-MRS)可以评估MAT。我们报告了患有神经性厌食症(AN)的青少年非负重半径的微结构受损，这些改变可能先于BMD缺陷。关于AN对青少年和年轻人负重胫骨的微结构和强度的影响，以及微结构和垫子的变化对强度估计的影响，缺乏数据。比较患有骨质疏松症和对照组的青少年/青壮年胫骨远端的强度估计与vBMD、骨大小和微结构以及脊柱垫的关系。这是一项横断面研究，研究对象为47名患有AN的青少年和55名对照组，年龄14-24岁，使用DXA评估骨密度和身体成分，并使用HRpQCT、扩展皮质分析、个体骨小梁分割和有限元分析评估胫骨远端vBMD、大小、微结构和强度。对19名AN和22名对照组的腰椎垫(1H-MRS)进行了评估。AN组的面骨密度Z-值低于对照组。在胫骨，AN的皮质孔隙度更大，总vBMD和皮质vBMD、皮质面积和厚度、骨小梁数量和强度估计值比对照组低。在AN内，强度估计与瘦质量、aBMD、vBMD、骨大小和微结构参数呈正相关。MAT在AN中较高，且与强度估计呈负相关。患有AN的青少年/青壮年在负重的胫骨和较高的脊柱垫上的微结构受损，与骨强度降低有关。
Altered bone microarchitecture and higher marrow adipose tissue (MAT) may reduce bone strength. High resolution pQCT (HRpQCT) allows assessment of volumetric BMD (vBMD), and size and microarchitecture parameters of bone, while 1H-magnetic resonance spectroscopy (1H-MRS) allows MAT evaluation. We have reported impaired microarchitecture at the non-weight bearing radius in adolescents with anorexia nervosa (AN) and that these changes may precede aBMD deficits. Data are lacking regarding effects of AN on microarchitecture and strength at the weight-bearing tibia in adolescents and young adults, and the impact of changes in microarchitecture and MAT on strength estimates. To compare strength estimates at the distal tibia in adolescents/young adults with AN and controls in relation to vBMD, bone size and microarchitecture, and spine MAT. This was a cross-sectional study of 47 adolescents/young adults with AN and 55 controls 14–24 years old that assessed aBMD and body composition using DXA, and distal tibia vBMD, size, microarchitecture and strength estimates using HRpQCT, extended cortical analysis, individual trabecular segmentation, and finite element analysis. Lumbar spine MAT (1H-MRS) was assessed in a subset of 19 AN and 22 controls. Areal BMD Z-scores were lower in AN than controls. At the tibia, AN had greater cortical porosity, lower total and cortical vBMD, cortical area and thickness, trabecular number, and strength estimates than controls. Within AN, strength estimates were positively associated with lean mass, aBMD, vBMD, bone size and microarchitectural parameters. MAT was higher in AN, and associated inversely with strength estimates. Adolescents/young adults with AN have impaired microarchitecture at the weight-bearing tibia and higher spine MAT, associated with reduced bone strength.
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影响因子：
6.2
作者：
Boutroy, Stephanie;Van Rietbergen, Bert;Delmas, Pierre D.
通讯作者：
Delmas, Pierre D.
影响因子：
2.4
作者：
Kreipke, Tyler C.;Garrison, Jacqueline G.;Niebur, Glen L.
通讯作者：
Niebur, Glen L.
DOI：
10.1249/mss.0000000000000574
发表时间：
2015-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Ackerman, Kathryn E.;Sokoloff, Natalia Cano;Misra, Madhusmita
通讯作者：
Misra, Madhusmita
影响因子：
5.8
作者：
Boutroy, S;Bouxsein, ML;Delmas, PD
通讯作者：
Delmas, PD
影响因子：
5.8
作者：
Bredella, Miriam A.;Fazeli, Pouneh K.;Klibanski, Anne
通讯作者：
Klibanski, Anne