Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer.
Microbial-Driven Immunological Memory and Its Potential Role in Microbiome Editing for the Prevention of Colorectal Cancer.
复制标题
微生物驱动的免疫记忆及其在微生物组编辑预防结直肠癌中的潜在作用。
DOI：
10.3389/fcimb.2021.752304
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发表时间：
2021
影响因子：
5.7
通讯作者：
Ernst PB
中科院分区：
文献类型：
--
作者：
Campillo-Gimenez L;Rios-Covian D;Rivera-Nieves J;Kiyono H;Chu H;Ernst PB
在过去的几年中，在了解细菌在胃肠道癌症发病机制中的作用方面取得了许多进展。从幽门螺杆菌被认为是第一种细菌致癌物和大多数胃癌的致病因子开始，最近的研究探讨了肠道微生物在结直肠癌中的作用。在消化道中，这些群落数量众多，并且与影响宿主健康的局部免疫/炎症反应具有复杂的相互关系。由于改变胃中的微生物组可以降低患胃癌的风险，因此改变远端微生物组可能会降低患结直肠癌的风险。迄今为止，很少有研究考虑到粘膜淋巴细胞依赖性免疫记忆可能会阻碍改变这些群落中微生物成分的尝试。本综述的目的是考虑影响结直肠癌的宿主-微生物相互作用的一些因素，并提出关于局部微生物群的免疫记忆反应如何影响改变肠道微生物组组成的任何尝试的问题。
Over the last several years, many advances have been made in understanding the role of bacteria in the pathogenesis of gastrointestinal cancers. Beginning with Helicobacter pylori being recognized as the first bacterial carcinogen and the causative agent of most gastric cancers, more recent studies have examined the role of enteric microbes in colorectal cancer. In the digestive tract, these communities are numerous and have a complex interrelationship with local immune/inflammatory responses that impact the health of the host. As modifying the microbiome in the stomach has decreased the risk of gastric cancer, modifying the distal microbiome may decrease the risk of colorectal cancers. To date, very few studies have considered the notion that mucosal lymphocyte-dependent immune memory may confound attempts to change the microbial components in these communities. The goal of this review is to consider some of the factors impacting host-microbial interactions that affect colorectal cancer and raise questions about how immune memory responses to the local microbial consortium affect any attempt to modify the composition of the intestinal microbiome.