Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence
Human Lymphatic Architecture and Dynamic Transport Imaged Using Near-infrared Fluorescence
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DOI：
10.1593/tlo.10190
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发表时间：
2010-12-01
影响因子：
5
通讯作者：
Sevick-Muraca, Eva M.
中科院分区：
文献类型：
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作者：
Rasmussen, John C.;Tan, I-Chih;Sevick-Muraca, Eva M.
背景技术背景：虽然淋巴功能的重要性是公认的，但缺乏实时成像方式限制了我们对其在许多疾病中的作用的理解。在一项0期探索性研究中，我们使用动态近红外（NIR）荧光成像来评估健康受试者和临床诊断为单侧水肿（LE）的受试者（一种在癌症幸存者中普遍存在的疾病）的淋巴结构和转运的极端情况。方法和结果：皮内注射25 μ g吲哚菁绿色（总最大剂量）后，对主动淋巴推进进行成像
BACKGROUND: Although the importance of lymphatic function is well recognized, the lack of real-time imaging modalities limits our understanding of its role in many diseases. In a phase 0 exploratory study, we used dynamic, near-infrared (NIR) fluorescence imaging to assess the extremes of lymphatic architecture and transport in healthy human subjects and in subjects clinically diagnosed with unilateral lymphedema (LE), a disease that can be prevalent in cancer survivors. METHODS AND RESULTS: Active lymphatic propulsion was imaged after intradermal injections of 25 mu g of indocyanine green (total maximum dose