Impact of cardiovascular risk factor control on long-term cardiovascular and all-cause mortality in the general population
Impact of cardiovascular risk factor control on long-term cardiovascular and all-cause mortality in the general population
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DOI：
10.1080/07853890.2016.1217035
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发表时间：
2016-01-01
影响因子：
4.4
通讯作者：
Ferrieres, Jean
中科院分区：
文献类型：
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作者：
Berard, Emilie;Bongard, Vanina;Ferrieres, Jean
目的：在临床试验中，降低心血管风险因素（CVRF）可降低心血管（CV）发病率和死亡率。我们评估了控制CVRF在基线对长期的全因和CV死亡率在一般population.Methods的影响：分析是基于第三次法国MONICA人口为基础的调查（1994-1997）。在入选后18年获得生命状态。统计分析是基于Cox-modeling.Results：约3402名年龄在35-64岁的参与者被纳入，569名（17%）出现2个或更多不受控制的CVRF，1194名（35%）有一个不受控制的CVRF，770名（23%）在治疗下所有CVRF都得到控制（或以前吸烟），869名（25%）没有表现出CVRF。在随访期间，发生了389例死亡（76例死于CV原因）。考虑到全因死亡率，发生1次未控制CVRF的受试者和发生2次或2次以上CVRF的受试者的校正风险比（aHR）分别为1.38 [1.03-1.83]（p=0.029）和1.80 [1.33-2.43]（p
Purpose: In clinical trials, lowering cardiovascular risk factors (CVRFs) reduces cardiovascular (CV) morbidity and mortality. We assessed the impact of controlling CVRFs at baseline on long-term all-cause and CV mortality in the general population.Methods: Analysis was based on the Third French MONICA population-based survey (1994-1997). Vital status was obtained 18 years after inclusion. Statistical analysis was based on Cox-modelling.Results: About 3402 participants aged 35-64 were included and 569 (17%) presented with 2 or more uncontrolled CVRFs, 1194 (35%) had one uncontrolled CVRF, 770 (23%) had all CVRFs controlled under treatment (or were former smokers) and 869 (25%) exhibited no CVRF. During the follow-up, 389 deaths occurred (76 were due to CV causes). Considering all-cause mortality, the adjusted hazard ratios (aHR) for subjects with one uncontrolled CVRF and for those with two or more were 1.38 [1.03-1.83] (p=0.029) and 1.80 [1.33-2.43](p