Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.
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发表时间：
1999-11
影响因子：
4
通讯作者：
J. Schlondorff;C. Blobel
中科院分区：
文献类型：
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作者：
J. Schlondorff;C. Blobel
金属蛋白酶分解素（ADAMs）作为受精和肿瘤坏死因子（TNF）等蛋白质外结构域加工的关键角色，以及它们在notch介导的信号传导、神经发生和肌肉融合中所起的作用，引起了我们的注意。ADAMs是一种完整的膜糖蛋白，包含一个与蛇毒整合素配体相关的分解素结构域和一个金属蛋白酶结构域（可以含有或缺乏催化位点）。在这里，我们回顾并批判性地讨论了ADAMs领域的当前主题，包括肥料在受精中的核心作用，TNF（）转化酶在蛋白质外畴加工中的作用，Kuzbanian在Notch信号传导中的作用，以及ADAMs与淀粉样前体蛋白加工之间的联系。
Metalloprotease-disintegrins (ADAMs) have captured our attention as key players in fertilization and in the processing of the ectodomains of proteins such as tumor necrosis factor () (TNF()), and because of their roles in Notch-mediated signaling, neurogenesis and muscle fusion. ADAMs are integral membrane glycoproteins that contain a disintegrin domain, which is related to snake-venom integrin ligands, and a metalloprotease domain (which can contain or lack a catalytic site). Here, we review and critically discuss current topics in the ADAMs field, including the central role of fertilin in fertilization, the role of the TNF() convertase in protein ectodomain processing, the role of Kuzbanian in Notch signaling, and links between ADAMs and processing of the amyloid-precursor protein.